| For: | Zijl FV, Mikulits W. Hepatospheres: Three dimensional cell cultures resemble physiological conditions of the liver. World J Hepatol 2010; 2(1): 1-7 [PMID: 21160950 DOI: 10.4254/wjh.v2.i1.1] |
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| URL: | https://www.wjgnet.com/1948-5182/full/v2/i1/1.htm |
| Number | Citing Articles |
| 1 |
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams, Steven D. Webb. Characterization of a functional C3A liver spheroid model. Toxicology Research 2016; 5(4) doi: 10.1039/C6TX00101G
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| 2 |
Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, Helen E. Colley, Craig Murdoch, Pratibha Mistry, Steven D. Webb. Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment. Toxicology in Vitro 2018; 48 doi: 10.1016/j.tiv.2018.01.023
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| 3 |
Tingxian Liu, Linda van den Berk, Joeri A. J. Wondergem, Ciqing Tong, Markus C. Kwakernaak, Bas ter Braak, Doris Heinrich, Bob van de Water, Roxanne E. Kieltyka. Squaramide‐Based Supramolecular Materials Drive HepG2 Spheroid Differentiation. Advanced Healthcare Materials 2021; 10(11) doi: 10.1002/adhm.202001903
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| 4 |
Xi Chen, Wen Jiang, Ayman Ahmed, Clare S. Mahon, Markus Müllner, Bocheng Cao, Tian Xia. Engineering Protective Polymer Coatings for Liver Microtissues. Chemical Research in Toxicology 2019; 32(1) doi: 10.1021/acs.chemrestox.8b00120
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| 5 |
Başak Tuğcu, Çağla Yarkent, Yunus Çelik, Ayşe Köse, Suphi S. Oncel. Comparison of HepG2 Cell Spheroid Formation Under Bioreactor Productions with Two Mixing Strategies by RCCS and CSTR. Microgravity Science and Technology 2025; 37(2) doi: 10.1007/s12217-025-10170-y
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| 6 |
Ramesh Pai Roopesh, Senthilkumar Muthusamy, Shiny Velayudhan, Arumugham Sabareeswaran, Pallickaveedu RajanAsari Anil Kumar. High‐throughput production of liver parenchymal microtissues and enrichment of organ‐specific functions in gelatin methacrylamide microenvironment. Biotechnology and Bioengineering 2022; 119(3) doi: 10.1002/bit.28010
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| 7 |
Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, Helen E. Colley, Craig Murdoch, Amy L. Harding, Pratibha Mistry, Steven D. Webb. Characterisation of a functional rat hepatocyte spheroid model. Toxicology in Vitro 2019; 55 doi: 10.1016/j.tiv.2018.12.014
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| 8 |
Júlia Vörösházi, Máté Mackei, Csilla Sebők, Patrik Tráj, Rege Anna Márton, Dávid Géza Horváth, Korinna Huber, Zsuzsanna Neogrády, Gábor Mátis. Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures. Scientific Reports 2024; 14(1) doi: 10.1038/s41598-024-51689-1
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| 9 |
Sau Fung Wong, Da Yoon No, Yoon Young Choi, Dong Sik Kim, Bong Geun Chung, Sang-Hoon Lee. Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model. Biomaterials 2011; 32(32) doi: 10.1016/j.biomaterials.2011.07.028
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| 10 |
Carlemi Calitz, Josias H. Hamman, Stephen J. Fey, Krzysztof Wrzesinski, Chrisna Gouws. Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective. Toxicology Mechanisms and Methods 2018; 28(5) doi: 10.1080/15376516.2017.1422580
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| 11 |
Michael G. Megaly, Diane Tobolt, Anthony An‐Fa Dahm Chen, Bat‐Erdene Namsrai, Benjamin Fisher, Joseph Sushil Rao, Srivasupradha Ramesh, Anudari Chimedtseren, Scott L. Nyberg, Mark Clemens, Charles Y. Lee, John C. Bischof, Erik B. Finger. The effect of rocking speed and cell inoculation density on hepatic spheroid size: A simple method for size modulation. Bioengineering & Translational Medicine 2026; doi: 10.1002/btm2.70154
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| 12 |
Priyanka Jayal, Padmanava Behera, Ranajoy Mullick, Subbaraya G. Ramachandra, Saumitra Das, Ashok Kumar, Anjali Karande. Responsive polymer‐assisted 3D cryogel supports Huh7.5 as in vitro hepatitis C virus model and ectopic human hepatic tissue in athymic mice. Biotechnology and Bioengineering 2021; 118(3) doi: 10.1002/bit.27651
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| 13 |
Patrina Gunness, Daniel Mueller, Valery Shevchenko, Elmar Heinzle, Magnus Ingelman-Sundberg, Fozia Noor. 3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies. Toxicological Sciences 2013; 133(1) doi: 10.1093/toxsci/kft021
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| 14 |
Pilar Sainz-Arnal, Iris Pla-Palacín, Natalia Sánchez-Romero, Manuel Almeida, Sara Morini, Estela Solanas, Alberto Lue, Trinidad Serrano-Aulló, Pedro M. Baptista. Principles of Regenerative Medicine. 2019; doi: 10.1016/B978-0-12-809880-6.00062-X
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| 15 |
M José Gómez-Lechón, Laia Tolosa, Isabel Conde, M Teresa Donato. Competency of different cell models to predict human hepatotoxic drugs. Expert Opinion on Drug Metabolism & Toxicology 2014; 10(11) doi: 10.1517/17425255.2014.967680
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| 16 |
Mahsa Sani, Sepideh Ebrahimi, Fatemeh Aleahmad, Mahin Salmannejad, Seyed Mojtaba Hosseini, Gelareh Mazarei, Tahereh Talaei-Khozani. Differentiation Potential of Breast Milk-Derived Mesenchymal Stem Cells into Hepatocyte-Like Cells. Tissue Engineering and Regenerative Medicine 2017; 14(5) doi: 10.1007/s13770-017-0066-x
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| 17 |
Dominik Witzigmann, Luca Quagliata, Susanne H. Schenk, Cristina Quintavalle, Luigi M. Terracciano, Jörg Huwyler. Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention. Hepatology Research 2016; 46(7) doi: 10.1111/hepr.12599
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| 18 |
Eric A. G. Blomme, Yvonne Will. Toxicology Strategies for Drug Discovery: Present and Future. Chemical Research in Toxicology 2016; 29(4) doi: 10.1021/acs.chemrestox.5b00407
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| 19 |
Kun Lieh Wu, Siou Han Chang, Ioannis Manousakas, Han Hsiang Huang, Benjamin Teong, Chin Wen Chuang, Shyh Ming Kuo. Effects of culturing media on hepatocytes differentiation using Volvox sphere as co-culturing vehicle. Biochemical and Biophysical Research Communications 2015; 458(3) doi: 10.1016/j.bbrc.2015.02.016
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| 20 |
Takeshi Hori, Osamu Kurosawa. A Three-Dimensional Cell Culture Method with a Micromesh Sheet and Its Application to Hepatic Cells. Tissue Engineering Part C: Methods 2018; 24(12) doi: 10.1089/ten.tec.2018.0269
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| 21 |
Simon Messner, Lisa Fredriksson, Volker M. Lauschke, Katrin Roessger, Claudia Escher, Magdalena Bober, Jens M. Kelm, Magnus Ingelman-Sundberg, Wolfgang Moritz. Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues. Applied In Vitro Toxicology 2018; 4(1) doi: 10.1089/aivt.2017.0022
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| 22 |
Ines Martin-Padura, Paola Marighetti, Alice Agliano, Federico Colombo, Leyre Larzabal, Miriam Redrado, Anne-Marie Bleau, Celia Prior, Francesco Bertolini, Alfonso Calvo. Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts. Laboratory Investigation 2012; 92(7) doi: 10.1038/labinvest.2012.65
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| 23 |
F. Malhão, R. Urbatzka, J.M. Navas, C. Cruzeiro, R.A.F. Monteiro, E. Rocha. Cytological, immunocytochemical, ultrastructural and growth characterization of the rainbow trout liver cell line RTL-W1. Tissue and Cell 2013; 45(3) doi: 10.1016/j.tice.2012.10.006
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| 24 |
Sara Ortica, Nadine Tarantino, Nathalie Aulner, Alain Israël, Neetu Gupta‐Rossi. The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors. The FASEB Journal 2014; 28(2) doi: 10.1096/fj.13-235903
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| 25 |
Phillip L. Lewis, Richard M. Green, Ramille N. Shah. 3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression. Acta Biomaterialia 2018; 69 doi: 10.1016/j.actbio.2017.12.042
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| 26 |
Mariangela Scalise, Fabiola Marino, Luca Salerno, Nunzia Amato, Claudia Quercia, Chiara Siracusa, Andrea Filardo, Antonio Chiefalo, Loredana Pagano, Giuseppe Misdea, Nadia Salerno, Antonella De Angelis, Konrad Urbanek, Giuseppe Viglietto, Daniele Torella, Eleonora Cianflone. Adult Multipotent Cardiac Progenitor-Derived Spheroids: A Reproducible Model of In Vitro Cardiomyocyte Commitment and Specification. Cells 2023; 12(13) doi: 10.3390/cells12131793
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| 27 |
Y Pang, K Montagne, M Shinohara, K Komori, Y Sakai. Liver tissue engineering based on aggregate assembly: efficient formation of endothelialized rat hepatocyte aggregates and their immobilization with biodegradable fibres. Biofabrication 2012; 4(4) doi: 10.1088/1758-5082/4/4/045004
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| 28 |
Eva Gijbels, Vânia Vilas-Boas, Neel Deferm, Lindsey Devisscher, Hartmut Jaeschke, Pieter Annaert, Mathieu Vinken. Mechanisms and in vitro models of drug-induced cholestasis. Archives of Toxicology 2019; 93(5) doi: 10.1007/s00204-019-02437-2
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| 29 |
Mary C. Regier, Kelly R. Stevens. Biofabrication and 3D Tissue Modeling. 2019; doi: 10.1039/9781788012683-00253
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| 30 |
Asmaa F. Khafaga, Shaker A. Mousa, Lotfi Aleya, Mohamed M. Abdel-Daim. Three-dimensional (3D) cell culture: a valuable step in advancing treatments for human hepatocellular carcinoma. Cancer Cell International 2022; 22(1) doi: 10.1186/s12935-022-02662-3
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| 31 |
Zahra Feizi, Ensieh Zahmatkesh, Zahra Farzaneh, Abbas Piryaei, Roberto Gramignoli, Andreas K. Nussler, Hossein Baharvand, Massoud Vosough. Prenatal liver stromal cells: Favorable feeder cells for long‐term culture of hepatic progenitor cells. Journal of Cellular Biochemistry 2019; 120(10) doi: 10.1002/jcb.28921
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| 32 |
Don Benjamin, Marco Colombi, Sravanth K. Hindupur, Charles Betz, Heidi A. Lane, Mahmoud Y. M. El-Shemerly, Min Lu, Luca Quagliata, Luigi Terracciano, Suzette Moes, Timothy Sharpe, Aleksandra Wodnar-Filipowicz, Christoph Moroni, Michael N. Hall. Syrosingopine sensitizes cancer cells to killing by metformin. Science Advances 2016; 2(12) doi: 10.1126/sciadv.1601756
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| 33 |
Michiharu Kawahara, Kotomu Miyazaki, Takahisa Anada, Shingo Kobayashi, Masaru Tanaka. Engineering Three-Dimensional Cellular Organization by Regulating Bound Water-Mediated Cell–Substrate Interactions for Disease Modeling. ACS Omega 2025; 10(45) doi: 10.1021/acsomega.5c09030
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| 34 |
Ming-Liang You, Yi-Jun Chen, Qing-Yun Chong, Ming-Ming Wu, Vijay Pandey, Ru-Mei Chen, Liang Liu, Lan Ma, Zheng-Sheng Wu, Tao Zhu, Peter E. Lobie. Trefoil factor 3 mediation of oncogenicity and chemoresistance in hepatocellular carcinoma is AKT-BCL-2 dependent. Oncotarget 2017; 8(24) doi: 10.18632/oncotarget.16950
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| 35 |
Huey‐Huey Chua, Daw‐Jen Tsuei, Po‐Huang Lee, Yung‐Ming Jeng, Jean Lu, Jia‐Feng Wu, De‐Shiuan Su, Ya‐Hui Chen, Chin‐Sung Chien, Pei‐Chi Kao, Chien‐Nan Lee, Rey‐Heng Hu, Yen‐Hsuan Ni, Mei‐Hwei Chang. RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma. Hepatology 2015; 62(5) doi: 10.1002/hep.27996
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| 36 |
Iftikhar Ali Khawar, Jong Kook Park, Eun Sun Jung, Myung Ah Lee, Suhwan Chang, Hyo-Jeong Kuh. Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma. Neoplasia 2018; 20(8) doi: 10.1016/j.neo.2018.05.008
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| 37 |
Maqsood Ali, Samantha L. Payne. Biomaterial-based cell delivery strategies to promote liver regeneration. Biomaterials Research 2021; 25(1) doi: 10.1186/s40824-021-00206-w
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| 38 |
Rafael Bornstein, Maria I. Macias, Paz de la Torre, Jesus Grande, Ana I. Flores. Human decidua-derived mesenchymal stromal cells differentiate into hepatic-like cells and form functional three-dimensional structures. Cytotherapy 2012; 14(10) doi: 10.3109/14653249.2012.706706
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| 39 |
Yunus Celik, Kadir Alptekin, S. Furkan Demirden, Suphi S. Oncel. A novel low shear horizontal bioreactor design for the production of animal cells: Effect of bioreactor dynamics on the 3D spheroid formation of HepG2. Biochemical Engineering Journal 2023; 196 doi: 10.1016/j.bej.2023.108952
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| 40 |
Syamal D. Bhattacharya, Zhiyong Mi, Lindsay J. Talbot, Hongtao Guo, Paul C. Kuo. Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: Concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers. Surgery 2012; 152(3) doi: 10.1016/j.surg.2012.06.011
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| 41 |
Indira Padmalayam, Mark J. Suto. Annual Reports in Medicinal Chemistry Volume 47. Annual Reports in Medicinal Chemistry 2012; 47 doi: 10.1016/B978-0-12-396492-2.00024-2
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| 42 |
Júlia Vörösházi, Máté Mackei, Csilla Sebők, Patrik Tráj, Rege A. Márton, Zsuzsanna Neogrády, Gábor Mátis. Role of T-2 toxin in the modulation of oxidative homeostasis and immune function in three-dimensional hepatic cell cultures of chicken origin. Frontiers in Veterinary Science 2026; 13 doi: 10.3389/fvets.2026.1759841
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| 43 |
Pujan Desai, Hubert Tseng, Glauco Souza. Assembly of Hepatocyte Spheroids Using Magnetic 3D Cell Culture for CYP450 Inhibition/Induction. International Journal of Molecular Sciences 2017; 18(5) doi: 10.3390/ijms18051085
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| 44 |
Jonathan A. Kyffin, Christopher R. Cox, Joseph Leedale, Helen E. Colley, Craig Murdoch, Pratibha Mistry, Steven D. Webb, Parveen Sharma. Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid‐Overlay Technique. Current Protocols in Toxicology 2019; 81(1) doi: 10.1002/cptx.87
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| 45 |
Elien Gevaert, Laurent Dollé, Thomas Billiet, Peter Dubruel, Leo van Grunsven, Aart van Apeldoorn, Ria Cornelissen, Michiya Matsusaki. High Throughput Micro-Well Generation of Hepatocyte Micro-Aggregates for Tissue Engineering. PLoS ONE 2014; 9(8) doi: 10.1371/journal.pone.0105171
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| 46 |
C.O. Lemley, M.E. Wilson. Effect of cytochrome P450 and aldo-keto reductase inhibitors on progesterone inactivation in primary bovine hepatic cell cultures. Journal of Dairy Science 2010; 93(10) doi: 10.3168/jds.2010-3165
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| 47 |
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough, Jan G. Hengstler. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 2013; 87(8) doi: 10.1007/s00204-013-1078-5
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| 48 |
April L. Rodd, Norma J. Messier, Charles A. Vaslet, Agnes B. Kane. A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquatic Toxicology 2017; 186 doi: 10.1016/j.aquatox.2017.02.018
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| 49 |
Yixuan Pang, Wenqi Zhang, Yuze Zhao, Huaying Hao, Huibin Wang, Jun Liang. A self-assembling peptide nanofiber hydrogel for biomaterials with rapid stimulation response to naturally positively charged group substances. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2024; 684 doi: 10.1016/j.colsurfa.2023.133118
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| 50 |
Kamal H. Hussein, Kyung M. Park, Jinn H. Ghim, Se R. Yang, Heung M. Woo. Three dimensional culture of HepG2 liver cells on a rat decellularized liver matrix for pharmacological studies. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2016; 104(2) doi: 10.1002/jbm.b.33384
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| 51 |
Anna Astashkina, David W. Grainger. Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments. Advanced Drug Delivery Reviews 2014; doi: 10.1016/j.addr.2014.02.008
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| 52 |
Tsai-Yu Lin, Chang Seok Ki, Chien-Chi Lin. Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels. Biomaterials 2014; 35(25) doi: 10.1016/j.biomaterials.2014.04.118
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