Copyright
©The Author(s) 2003.
World J Gastroenterol. Aug 15, 2003; 9(8): 1836-1839
Published online Aug 15, 2003. doi: 10.3748/wjg.v9.i8.1836
Published online Aug 15, 2003. doi: 10.3748/wjg.v9.i8.1836
Prapranolol group | Control group | Risk difference and its 95%CI (%) | |||
Total | Bled | Total | Bled | ||
Primary prevention | |||||
Pascal (1984) | 34 | 1 | 35 | 9 | -23 [-38, -7] |
Mills (1987) | 38 | 19 | 43 | 33 | -27 [-47, -6] |
Pascal (1987) | 118 | 20 | 112 | 30 | -10 [-20, 1] |
Italian (1988) | 85 | 16 | 89 | 27 | -12 [-24, 1] |
Strauss (1988) | 20 | 4 | 16 | 4 | -5 [-33, 23] |
Colman (1990) | 23 | 8 | 25 | 2 | 27 [5, 49] |
Andreani (1990) | 43 | 2 | 41 | 13 | -27 [-43,-11] |
Conn (1991) | 51 | 4 | 51 | 14 | -20 [-34, -5] |
Prova (1991) | 68 | 23 | 72 | 19 | 7 [-8, 23] |
Subtotal | 480 | 97 | 484 | 151 | -11 [-21, -1] |
Overall effect | Z = -2.15 | P = 0.03 | |||
Secondary prevention | |||||
Burroughs (1983) | 26 | 14 | 22 | 13 | -5 [-33, 23] |
Lebrec (1984) | 38 | 6 | 36 | 23 | -48 [-68,-29] |
Cerbelaud (1986) | 42 | 17 | 42 | 33 | -38 [-57,-19] |
Villeneuve (1986) | 42 | 32 | 37 | 30 | -5 [-23, 13] |
Queuniet (1987) | 51 | 29 | 48 | 31 | -8 [-27, 11] |
Marbet (1988) | 10 | 2 | 10 | 9 | -70 [-101,-39] |
Colombo (1989) | 32 | 8 | 30 | 14 | -22 [-45, 2] |
Sheen (1989) | 18 | 8 | 18 | 15 | -39 [-68,-10] |
Garden (1990) | 38 | 20 | 43 | 36 | -31 [-50,-12] |
Colman (1990) | 26 | 9 | 26 | 13 | -15 [-42, 11] |
Perez-Ayuso (1991) | 26 | 16 | 28 | 24 | -24 [-47, -1] |
Calès (1999) | 102 | 3 | 104 | 4 | -1 [-6, 4] |
Subtotal | 451 | 164 | 444 | 245 | -25 [-39,-10] |
Overall effect | Z = -3.34 | P = 0.0008 | |||
All trials | |||||
Total | 931 | 261 | 928 | 396 | -18 [-25, -10] |
Overall effect | Z = -4.38 | P = 0.00001 |
Prapranolol group | Control group | Risk difference and its 95%CI (%) | |||
Total | Death | Total | Death | ||
Primary prevention | |||||
Pascal (1984) | 34 | 1 | 35 | 13 | -34 [-51, -17] |
Mills (1987) | 38 | 15 | 43 | 19 | -5 [-26, 17] |
Pascal (1987) | 118 | 25 | 112 | 40 | -15 [-26, -3] |
Italian (1988) | 85 | 30 | 89 | 22 | 11 [-3, 24] |
Strauss (1988) | 20 | 7 | 16 | 7 | -9 [-41, 23] |
Colman (1990) | 23 | 6 | 25 | 7 | -2 [-27, 23] |
Andreani (1990) | 43 | 13 | 41 | 18 | -14 [-34, 7] |
Conn (1991) | 51 | 8 | 51 | 11 | -6 [-21, 9] |
Prova (1991) | 68 | 7 | 72 | 14 | -9 [-21, 3] |
Subtotal | 480 | 112 | 484 | 151 | -9 [-18, -1] |
Overall effect | Z = -2.11 | P = 0.03 | |||
Secondary prevention | |||||
Burroughs (1983) | 26 | 4 | 22 | 5 | -7 [-30, 15] |
Lebrec (1984) | 38 | 3 | 36 | 8 | -14 [-30, 2] |
Cerbelaud (1986) | 42 | 5 | 42 | 12 | -17 [-33, 0] |
Villeneuve (1986) | 42 | 19 | 37 | 14 | 7 [-14, 29] |
Queuniet (1987) | 51 | 12 | 48 | 13 | -4 [-21, 14] |
Marbet (1988) | 10 | 1 | 10 | 3 | -20 [-54, 14] |
Colombo (1989) | 32 | 4 | 30 | 7 | -11 [-30, 8] |
Sheen (1989) | 18 | 0 | 18 | 2 | -11 [-28, 6] |
Garden (1990) | 38 | 14 | 43 | 19 | -7 [-29, 14] |
Colman (1990) | 26 | 1 | 26 | 1 | 0 [-10, 10] |
Perez-Ayuso (1991) | 26 | 4 | 28 | 7 | -10 [-31, 12] |
Calès (1999) | 102 | 9 | 104 | 10 | -1 [-9, 7] |
Subtotal | 451 | 76 | 444 | 101 | -5 [-9, -1] |
Overall effect | Z = -2.26 | P = 0.02 | |||
All trials | |||||
Total | 931 | 188 | 928 | 252 | -7 [-12, -3] |
Overall effect | Z = -3.44 | P = 0.0006 |
- Citation: Cheng JW, Zhu L, Gu MJ, Song ZM. Meta analysis of propranolol effects on gastrointestinal hemorrhage in cirrhotic patients. World J Gastroenterol 2003; 9(8): 1836-1839
- URL: https://www.wjgnet.com/1007-9327/full/v9/i8/1836.htm
- DOI: https://dx.doi.org/10.3748/wjg.v9.i8.1836