Brief Reports
Copyright ©The Author(s) 2003.
World J Gastroenterol. Aug 15, 2003; 9(8): 1836-1839
Published online Aug 15, 2003. doi: 10.3748/wjg.v9.i8.1836
Table 1 Point estimates and 95%CIs of the risk difference of gastrointestinal hemorrhage
Prapranolol group
Control group
Risk difference and its 95%CI (%)
TotalBledTotalBled
Primary prevention
Pascal (1984)341359-23 [-38, -7]
Mills (1987)38194333-27 [-47, -6]
Pascal (1987)1182011230-10 [-20, 1]
Italian (1988)85168927-12 [-24, 1]
Strauss (1988)204164-5 [-33, 23]
Colman (1990)23825227 [5, 49]
Andreani (1990)4324113-27 [-43,-11]
Conn (1991)5145114-20 [-34, -5]
Prova (1991)682372197 [-8, 23]
Subtotal48097484151-11 [-21, -1]
Overall effectZ = -2.15P = 0.03
Secondary prevention
Burroughs (1983)26142213-5 [-33, 23]
Lebrec (1984)3863623-48 [-68,-29]
Cerbelaud (1986)42174233-38 [-57,-19]
Villeneuve (1986)42323730-5 [-23, 13]
Queuniet (1987)51294831-8 [-27, 11]
Marbet (1988)102109-70 [-101,-39]
Colombo (1989)3283014-22 [-45, 2]
Sheen (1989)1881815-39 [-68,-10]
Garden (1990)38204336-31 [-50,-12]
Colman (1990)2692613-15 [-42, 11]
Perez-Ayuso (1991)26162824-24 [-47, -1]
Calès (1999)10231044-1 [-6, 4]
Subtotal451164444245-25 [-39,-10]
Overall effectZ = -3.34P = 0.0008
All trials
Total931261928396-18 [-25, -10]
Overall effectZ = -4.38P = 0.00001
Table 2 Point estimates and 95%CIs of the risk difference of death
Prapranolol group
Control group
Risk difference and its 95%CI (%)
TotalDeathTotalDeath
Primary prevention
Pascal (1984)3413513-34 [-51, -17]
Mills (1987)38154319-5 [-26, 17]
Pascal (1987)1182511240-15 [-26, -3]
Italian (1988)8530892211 [-3, 24]
Strauss (1988)207167-9 [-41, 23]
Colman (1990)236257-2 [-27, 23]
Andreani (1990)43134118-14 [-34, 7]
Conn (1991)5185111-6 [-21, 9]
Prova (1991)6877214-9 [-21, 3]
Subtotal480112484151-9 [-18, -1]
Overall effectZ = -2.11P = 0.03
Secondary prevention
Burroughs (1983)264225-7 [-30, 15]
Lebrec (1984)383368-14 [-30, 2]
Cerbelaud (1986)4254212-17 [-33, 0]
Villeneuve (1986)421937147 [-14, 29]
Queuniet (1987)51124813-4 [-21, 14]
Marbet (1988)101103-20 [-54, 14]
Colombo (1989)324307-11 [-30, 8]
Sheen (1989)180182-11 [-28, 6]
Garden (1990)38144319-7 [-29, 14]
Colman (1990)2612610 [-10, 10]
Perez-Ayuso (1991)264287-10 [-31, 12]
Calès (1999)102910410-1 [-9, 7]
Subtotal45176444101-5 [-9, -1]
Overall effectZ = -2.26P = 0.02
All trials
Total931188928252-7 [-12, -3]
Overall effectZ = -3.44P = 0.0006