p53 protein expression and CA19.9 values in differential cytological diagnosis of pancreatic cancer complicated with chronic pancreatitis and chronic pancreatitis

Table 1 Patients with p53 protein overexpression and high serum CA19.9 with cytologically diagnosed pancreatic disease (n = 24)

Histological diagnosis	Cytology
	Patient n(%)	Malignant cells	Suspicious cells	Insufficient material	Non-malignant cells
Malignant diseases
PC	9(37.5) p53(+)	2/5	1/1	1/1	0/2
	CA19.9 ≥ 37 U/ml	3/5	1/1	0/1	0/2
Benign disease
IMH	13(54.2) p53(+)	0	0/5	0/4	0/4
	CA19.9 ≥ 37 U/ml	0	2/5	1/4	0/4
Adenoma	2(8.3)p53(+)	0	0/2	0	0
	CA19.9 ≥ 37 U/ml	0	0/2	0	0

PC: pancreatic cancer; IMH: inflammatory mass of the head of pancreas.

Table 2 Assay effectiveness in patients with pancreatic diseases (n = 24)

Assay	SensitivityTP/(TP + FN)	SpecificityTN/(FP + TN)	Predictive value ofpositive test TP/(TP + FP)	Efficiency(TP + TN)/Total
Cytology alone	5/(5 + 3) = 0.63	10/(0 + 10) = 1.00	5/(5 + 0) = 1.00	(5 + 10)/24 = 0.63
CA19.9 > 37 U/ml	4/(4 + 5) = 0.44	12/(3 + 12) = 0.80	4/(4 + 3) = 0.57	(4 + 12)/24 = 0.67
P53( + )	4/(4 + 5) = 0.44	15/(0 + 15) = 1.00	4/(4 + 0) = 1.00	(4 + 15)/24 = 0.79
Cytology + CA19.9	6/(6 + 3) = 0.67	12/(12 + 3) = 0.80	6/(6 + 3) = 0.67	(6 + 12)/24 = 0.67
Cytology + P53	7/(7 + 2) = 0.78	15/(15 + 0) = 1.00	7/(7 + 0) = 1.00	(7 + 15)/24 = 0.92
Cytology + P53 + CA19.9	7/(7 + 2) = 0.78	12(3 + 12) = 0.80	7(7 + 3) = 0.70	(7 + 12)/24 = 0.79

TP: true-positive; FN: false-negative; FP: false-positive; TN: true-negative.