Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients

doi:10.3748/wjg.v9.i8.1739

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Aug 15, 2003 (publication date) through Feb 24, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Aug 15, 2003; 9(8): 1739-1742
Published online Aug 15, 2003. doi: 10.3748/wjg.v9.i8.1739

Table 1 Comparison of biochemistry characteristics in all types of patients with or without GBV-C infection

Group	n	ALT/IU·L^-1	AST/IU·L^-1	TBil/μmol·L^-1	DBil/μmol·L^-1	Tp/g·L^-1
Acute hepatitis B
GBV-C RNA(+)	13	1173.92 ± 961.98	565.69 ± 405.32	5.18 ± 3.47	3.54 ± 2.66	68.44 ± 12.14
GBV-C RNA(-)	33	1380.27 ± 906.14	620.06 ± 405.32	6.52 ± 6.61	4.57 ± 4.51	67.84 ± 12.42
Chronic hepatitis B
GBV-C RNA(+)	24	366.33 ± 237.36	289.42 ± 201.32	6.48 ± 7.34	3.98 ± 4.50	71.30 ± 8.57
GBV-C RNA(-)	35	312.91 ± 432.82	227.29 ± 292.17	3.29 ± 5.58	2.21 ± 4.24	71.06 ± 7.66
Liver cirrhosis
GBV-C RNA(+)	30	71.67 ± 74.13	96.73 ± 87.21	5.54 ± 7.44	3.62 ± 5.33	66.46 ± 8.75
GBV-C RNA(-)	34	92.68 ± 80.33	106.15 ± 94.81	7.67 ± 10.30	5.20 ± 5.80	62.58 ± 10.99
Total
GBV-C RNA(+)	67	400.51 ± 585.36	255.22 ± 301.71	5.73 ± 6.81	3.69 ± 4.46	68.80 ± 9.61
GBV-C RNA(-)	102	578.63 ± 807.04	314.98 ± 345.05	5.85 ± 7.85	3.87 ± 4.80	67.21 ± 10.92

No significant difference (P > 0.05) was found in all the biochemistry characteristics between hepatitis B patients with or without GBV-C infection.

Table 2 Comparison of serum ALT and AST in dialysis patients with different virus infection

Group	n	Average dialysis times	ALT/IU·L^-1	AST/IU·L^-1
(1) HBV DNA(+)
HCV RNA(-)	11	243.75 ± 224.53	31.63 ± 22.32	35.12 ± 18.06
GBV-C RNA(-)
(2) HBV DNA(-)
HCV RNA(+)	6	306.67 ± 296.41	30.67 ± 9.45	25.00 ± 12.28
GBV-C RNA(-)
(3) HBV DNA(-)
HCV RNA(-)	8	353.40 ± 309.45	20.67 ± 11.72	17.00 ± 1.00
GBV-C RNA(+)
(4) HBV DNA(-)
HCV RNA(-)	37	116.45 ± 103.02	15.37 ± 6.83	20.00 ± 7.04
GBV-C RNA(-)

Table 3 Comparison of biochemistry characteristics between chronic hepatitis B patients with or without GBV-C infection

GBV-C RNA	n	A/G	ALT/IU·L^-1	AST/IU·L^-1	TBil/μmol·L^-1
(1) Positive group	24	1.65 ± 0.26	90.84 ± 48.43	43.21 ± 31.56	5.91 ± 1.86
(2) Negative group	71	1.63 ± 0.21	95.36 ± 51.96	44.45 ± 38.07	7.66 ± 1.95

No significant difference (P > 0.05) was found in all the biochemistry characteristics between the two groups.

Table 4 Comparison of biochemistry characteristics between chronic hepatitis C patients with or without GBV-C infection

GBV-C RNA	n	A/G	ALT/IU·L^-1	AST/IU·L^-1	TBil/μmol·L^-1
(1) Positive group	23	1.82 ± 0.30	110.23 ± 59.61	45.96 ± 40.11	4.53 ± 1.55
(2) Negative group	57	1.65 ± 0.25	97.65 ± 56.74	52.94 ± 48.00	5.77 ± 1.73

No significant difference (P > 0.05) was found in all the biochemistry characteristics between the two groups.

Table 5 Comparison of biochemistry characteristics between chronic hepatitis B patients with or without GBV-C infection at the 6-month follow-up

Group	n	A/G	ALT/IU·L^-1	AST/IU·L^-1	TBil/μmol·L^-1
(1) HBV DNA(+)	14	1.74 ± 0.19	93.29 ± 60.67	29.14 ± 13.87	7.64 ± 5.47
GBV-C RNA(+)
(2) HBV DNA (+)	58	1.73 ± 0.18	62.33 ± 41.67	27.68 ± 11.99	6.10 ± 2.09
GBV-C RNA (-)
(3) HBV DNA (-)	7	1.61 ± 0.11	30.00 ± 7.80	21.57 ± 8.18	7.57 ± 3.41
GBV-C RNA (+)
(4) HBV DNA (-)	16	1.64 ± 0.14	32.65 ± 17.01	26.65 ± 11.96	7.71 ± 2.76
GBV-C RNA (-)

Significant difference (P < 0.05) was found only in ALT between group 1 and group 3, group 2 and group 4. No significant dif-ference (P > 0.05) was found in other biochemistry characteris-tics among the 4 groups.

Table 6 Comparison of biochemistry characteristics between chronic hepatitis C patients with or without GBV-C infection at the 6-month follow-up

Group	n	A/G	ALT/IU·L^-1	AST/IU·L^-1	TBil/μmol·L^-1
(1) HCV RNA(+)	11	1.76 ± 0.17	127.11 ± 82.12	41.13 ± 19.07	7.49 ± 5.82
GBV-C RNA(+)
(2) HCV RNA(+)	48	1.82 ± 0.20	71.62 ± 47.74	26.05 ± 12.49	7.97 ± 3.91
GBV-C RNA (-)
(3) HCV RNA (-)	8	1.60 ± 0.13	33.11 ± 8.08	22.97 ± 9.78	7.26 ± 4.25
GBV-C RNA(+)
(4) HCV RNA (-)	13	1.60 ± 0.14	30.74 ± 20.01	24.65 ± 11.84	7.65 ± 3.23
GBV-C RNA (-)

Significant difference (P < 0.05) was found both in ALT between group 1 and group 3, group 2 and group 4, and in AST between group 1 and group 4. No significant difference (P > 0.05) was found in other biochemistry characteristics among the 4 groups.

Table 7 Comparison of biochemistry characteristics between chronic hepatitis B patients with or without GBV-C infection after 20 months

Group	n	ALT/IU·L^-1	AST/IU·L^-1
(1) HBV DNA(+)	8	52.13 ± 44.90	44.25 ± 28.42
GBV-C RNA(+)
(2) HBV DNA (+)	30	44.40 ± 37.26	34.67 ± 24.23
GBV-C RNA (-)
(3) HBV DNA (-)	8	28.14 ± 15.36	25.29 ± 17.21
GBV-C RNA (+)
(4) HBV DNA (-)	24	25.15 ± 11.59	25.73 ± 13.16
GBV-C RNA (-)

Significant difference (P < 0.05) was found only in ALT and AST between group 1 and group 3, and group 2 and group 4.

Table 8 Comparison of biochemistry characteristics between chronic hepatitis C patients with or without GBV-C infection after 20 months

Group	n	ALT/IU·L^-1	AST/IU·L^-1
(1) HCV RNA(+)	6	72.24 ± 73.87	49.29 ± 48.49
GBV-C RNA(+)
(2) HCV RNA(+)	22	42.43 ± 39.10	32.91 ± 30.57
GBV-C RNA (-)
(3) HCV RNA (-)	7	26.98 ± 24.47	25.11 ± 19.07
GBV-C RNA(+)
(4) HCV RNA (-)	29	25.39 ± 13.16	26.74 ± 16.99
GBV-C RNA (-)

Significant difference (P < 0.05) was found only in ALT and AST between group 1 and group 3, and group 2 and group 4.

Citation: Zhu WF, Yin LM, Li P, Huang J, Zhuang H. Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients. World J Gastroenterol 2003; 9(8): 1739-1742
URL: https://www.wjgnet.com/1007-9327/full/v9/i8/1739.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i8.1739