Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products

Table 1 PTEN expression in adjacent epithelial cells and cancer cells of primary gastric cancer

Groups	n	PTEN expression
		-	+	++	+++	PR(%)
Adjacent epithelial cells	113	12	10	23	68	89.4
Primary cancer cells	113	51	13	11	38	54.9a

Notes: PR: positive rate,

^aP = 0.000 (χ² = 33.474, Pearson’R = 0.385).

Table 2 Relationship between expression of PTEN in primary foci and clinicopathological features of gastric cancer

Clinicopathological features	n	PTEN expression					rs	P value
		-	+	++	+++	PR(%)
Tumor size							0.045	0.639
< 4 cm	47	20	6	4	17	57.4
≥ 4 cm	66	31	7	7	21	53.0
Borrmann’s Classification							0.070	0.544
I/II	28	12	3	3	10	57.1
III/IV	59	30	5	6	18	49.2
Invasive depth							0.274	0.003
Above submucosa	26	7	4	2	13	73.1
Muscularis propria	34	14	2	4	14	58.8
Below subserosa	53	30	7	5	11	56.6
Metastasis							0.197	0.036
Negative	76	28	10	8	29	62.7
Positive	38	23	3	3	9	39.5
TNM staging							0.129	0.172
O	18	7	4	1	6	61.1
I	28	11	2	2	13	60.7
II	40	19	3	5	13	52.5
III	17	7	3	3	4	58.8
IV	10	7	1	0	2	30.0
Growth pattern							0.282	0.008
Mass	23	8	2	2	11	65.2
Nest	30	12	3	4	11	60.0
Diffuse	34	22	3	3	6	35.3
Lauren’s Classification							0.345	0.000
Intestinal type	36	8	2	6	20	77.8
Diffuse type	57	32	10	3	12	43.9
Mixed type	20	11	1	2	6	45.0
Histological classification							0.262	0.005
Differentiated	53	18	3	8	24	66.0
Undifferentiated	60	33	10	3	14	45.0

Notes: PR: positive rate.

Table 3 Relationship between expression of PTEN expression and MVD in primary gastric cancer

PTENexpression	n	MVD (mean ± standard error)	F value	P value
-	51	52.53 ± 25.47	5.558	0.020
+~+++	62	41.84 ± 22.69
Total	113	46.67 ± 24.47

Table 4 Relationship between expression of PTEN and Caspase-3 in primary gastric cancer cells

PTEN expression	n	Caspase-3 expression
		-	+~+++	PR(%)
-	51	44	7	13.7a
+~+++	62	32	30	48.4
Total	113	76	37	32.7

Notes: PR: positive rate.

^aP = 0.000 (χ² = 15.266, Pearson’s R = 0.368).