Effect of Sea buckthorn on liver fibrosis: A clinical study

Table 1 Measurements of TNFα, IL-6, LN, type IV collagen (¯x ± s)

Group	n	TNFα(ng/L)	IL-6(ng/L)	LN(μg/L)	Type IV(ng/L)
A	30	19.6 ± 3.2	15.1 ± 2.8	374.1 ± 31.2	250.9 ± 22.6
B	20	6.7 ± 1.2	3.8 ± 1.1	99.4 ± 6.8	51.8 ± 4.6
t value		2.419	2.961	2.618	2.997
P value		< 0.05	< 0.05	< 0.05	< 0.05

Table 2 Normalization rates of AST, ALT (¯x ± s)

Group	AST (IU/L)		Normalization rate(%)	ALT (IU/L)		Normalization rate(%)
	Before treatment	After treatment		Before treatment	After treatment
A	59.87 ± 26.70	49.03 ± 18.99	24/30(80)a	50.57 ± 32.47	44.12 ± 26.05	24/30(80)a
B	154.75 ± 20.21	47.85 ± 23.53	10/18(56)	41.65 ± 23.54	39.15 ± 16.68	10/18(56)

^aP < 0.05 vs controls.

Table 3 Parameters of liver fibrosis (¯x ± s)

Parameters	Group	Before treatment	After treatment	Comparison of two groups
				Stat Z	P value
III (ng/l)	A	428.43 ± 196.02	149.43 ± 75.91
	B	423.56 ± 251.41	169.80 ± 138.94	0.0403	0.0394
IV (ng/l)	A	123.98 ± 81.22	70.00 ± 34.45
	B	178.32 ± 89.45	139.85 ± 98.15	0.0393	0.0384
LN (μg/l)	A	210.91 ± 165.12	136.51 ± 105.56
	B	211.56 ± 188.91	156.00 ± 100.00	0.0073	0.0070
HA (μg/l)	A	516.74 ± 338.75	240.56 ± 169.78
	B	494.74 ± 272.26	387.16 ± 196.28	0.0148	0.0144

Wilcoxon rank test.

Table 4 Changes of TBA, PT, Alb (¯x ± s)

Parameters	Group	Before treatment	After treatment	Before treatment		Before/after treatment		Comparison of two groups before/after treatment
				Stat(Z)	P value	Stat(t)	P value	Stat (S)	P value
TBA (ng/l)	A	38.70 ± 27.50	22.83 ± 12.28			189.32	0.0001
	B	40.50 ± 34.02	38.55 ± 22.60	0.751	0.743	35.55	0.1922	545.0	0.0003
PT (sec)	A	14.57 ± 0.97	13.50 ± 0.73			7.443	0.0001
	B	15.15 ± 0.93	14.40 ± 0.74	4.35	0.048	5.252	0.0001	2.21	0.1415
Alb (g/l)	A	34.07 ± 9.35	35.13 ± 7.13			1.205	0.238
	B	27.45 ± 7.41	27.40 ± 6.25	7.02	0.010	0.053	0.958	0.48	0.4887

Signed rank test and Wilcoxon rank test.