Colorectal Cancer
Copyright ©The Author(s) 2003.
World J Gastroenterol. Jun 15, 2003; 9(6): 1227-1230
Published online Jun 15, 2003. doi: 10.3748/wjg.v9.i6.1227
Table 1 Relationship between clinicopathologic factors and VEGF expression (n = 97)
Variablesn (%)VEGF expression
+ n(%)- n(%)P value
Age
< 45 years3626(72.2)10(27.8)
> 45 years6142(68.8)19(31.2)
Sex
Male5841(74.1)17(25.9)
Female3927(68.9)12(31.1)
Different differentiation
Well2815(51.1)13(48.9)
Moderate3626(72.2)10(27.8)
Poor3327(81.8)6(18.2)0.014
Stage
I97(77.8)2(22.2)
II3827(71.1)11(28.9)
III3223(72.2)9(27.8)
IV1811(61.5)7(38.5)
Table 2 Relationship between clinicopathologic factors and MVD (n = 97)
VariablesnMVD
high MVDlow MVDP value
Age
< 45 years3620(55.6)16(44.4)
> 45 years6133(54.3)28(45.7)
Sex
Male5832(55.2)26(44.8)
Female3921(53.8)18(46.2)
Different differentiation
Well2812(42.9)16(57.1)
Moderate3620(55.6)16(44.4)
Poor3321(63.6)12(36.4)0.028
Stage
I95(55.6)4(44.4)
II3820(52.6)18(47.4)
III3218(56.3)14(43.7)
IV1810(55.6)8(44.4)
Table 3 Relationship between MVD and VEGF expression
VariableMVDP value
VEGF (+)213.4 ± 12.8
Expression (-)138.7 ± 19.40.027
Table 4 Multivariate analysis of overall survival by Cox proportional hazards model
VariableCategoriesHazard ratioSEMP value
Age> 45 years versus < 45 years1.8770.3796
SexMale versus female1.2160.4071
DifferentiationPoor versus others2.3610.24380.0217
StageI, II versus III, IV2.9730.19760.0012
VEGF(+) versus (-)1.1640.3874
MVD> 187.6 versus < 187.62.5260.21260.0314