Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma

Table 1 Relationship between clinicopathologic factors and VEGF expression (n = 97)

Variables	n (%)	VEGF expression
		+ n(%)	- n(%)	P value
Age
< 45 years	36	26(72.2)	10(27.8)
> 45 years	61	42(68.8)	19(31.2)
Sex
Male	58	41(74.1)	17(25.9)
Female	39	27(68.9)	12(31.1)
Different differentiation
Well	28	15(51.1)	13(48.9)
Moderate	36	26(72.2)	10(27.8)
Poor	33	27(81.8)	6(18.2)	0.014
Stage
I	9	7(77.8)	2(22.2)
II	38	27(71.1)	11(28.9)
III	32	23(72.2)	9(27.8)
IV	18	11(61.5)	7(38.5)

P < 0.05 vs Well differentiated group.

Table 2 Relationship between clinicopathologic factors and MVD (n = 97)

Variables	n	MVD
		high MVD	low MVD	P value
Age
< 45 years	36	20(55.6)	16(44.4)
> 45 years	61	33(54.3)	28(45.7)
Sex
Male	58	32(55.2)	26(44.8)
Female	39	21(53.8)	18(46.2)
Different differentiation
Well	28	12(42.9)	16(57.1)
Moderate	36	20(55.6)	16(44.4)
Poor	33	21(63.6)	12(36.4)	0.028
Stage
I	9	5(55.6)	4(44.4)
II	38	20(52.6)	18(47.4)
III	32	18(56.3)	14(43.7)
IV	18	10(55.6)	8(44.4)

P < 0.05 vs Well differentiated group.

Table 3 Relationship between MVD and VEGF expression

Variable	MVD	P value
VEGF (+)	213.4 ± 12.8
Expression (-)	138.7 ± 19.4	0.027

P < 0.05 vs VEGF (-) group.

Table 4 Multivariate analysis of overall survival by Cox proportional hazards model

Variable	Categories	Hazard ratio	SEM	P value
Age	> 45 years versus < 45 years	1.877	0.3796
Sex	Male versus female	1.216	0.4071
Differentiation	Poor versus others	2.361	0.2438	0.0217
Stage	I, II versus III, IV	2.973	0.1976	0.0012
VEGF	(+) versus (-)	1.164	0.3874
MVD	> 187.6 versus < 187.6	2.526	0.2126	0.0314

P < 0.05 vs Stage I, II group.