hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer

Table 1 Odds ratios for colon cancer according to the geno-types of hOGG1 Ser326Cys polymorphism

	Number (%)		OR (95%CI)	P for trend
	Controls	Cases
Ser/Ser	52 (21.1)	24 (19.2)	1.00
Ser/Cys	131 (53.0)	66 (52.8)	1.09 (0.60-2.00)	P = 0.871
Cys/Cys	64 (25.9)	35 (28.0)	1.18 (0.60-2.35)
Total	247 (100)	125 (100)

Table 2 ORs for colon cancer according to individual habits and familial history of colon cancer with reference to the hOGG1 Ser326Cys polymorphism

	Total			hOGG1 Ser326Cys polymorphi sm
	Ca/Co	OR	95%CI	Ser/Ser + ser/Cys			Cys/Cys
				Ca/Co	OR	95%CI	Ca/Co	OR	95%CI
Smoking
No	44/106	1	-	35/75	1	-	9/31	1	-
Yes	81/141	1.53	0.94-2.52	55/108	1.08	0.62-1.84	26/33	2.75	1.07-7.53
Drinking
< 2times/wk	73/161	1	-	53/122	1	-	20/39	1	-
> 2times/wk	52/86	1.37	0.87-2.32	37/61	1.49	0.87-2.77	15/25	1.21	0.49-3.02
Meat
< 2time/week	66/159	1	-	52/112		-	14/47	1	-
> 2time/week	59/88	1.72	1.12-2.76	38/71	1.27	0.73-2.13	21/17	4.31	1.64-11.48
Vegetable intake
Low	50/89	1	-	36/70	1	-	14/19	1	-
High	75/158	0.8	0.49-1.31	54/113	0.9	0.46-1.67	21/45	1.55	0.50-4.19
Soybean product
< 3/wk	55/115	1	37/87	1		-	18/28	1	-
> 3/wk	70/132	1.11	0.70-1.75	53/96	1.3	0.76-2.23	17/36	0.73	0.30-1.82
Activity
< 4 hs/wk	61/104	1	-	43/75		-	18/29	1	-
> 4hs/wk	64/143	0.76	0.48-1.20	47/108	0.76	0.44-1.30	17/35	0.78	0.32-1.94
Familial history of colon cancer
No	84/185	1	-	62/138		-	22/47	1	-
Yes	41/62	1.46	0.80-2.40	28/45	1.38	0.76-2.51	13/17	1.63	0.62-4.32

Denotes: Ca/Co = Cases/Controls.