Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease

Table 1 Changes in pulmonary function and bronchial respon-siveness in asthmatic patients with GERD (mean values ± SD)

Index	Group A n = 15		Group B n = 15
	Before therapy	After therapy	Before therapy	After therapy
VC (L)	2.9 ± 0.4	2.7 ± 0.9	2.8 ± 0.7	3.7 ± 0.7ab
VC%	86.3 ± 14.6	85.9 ± 1.9	84.9 ± 18.9	111.2 ± 13.6ab
FVC (L)	2.9 ± 0.6	2.7 ± 0.8	2.8 ± 0.4	3.6 ± 0.9ab
FVC%	88.4 ± 19.2	85.1 ± 23.6	86.3 ± 21.7	102.6 ± 16.1ab
FEV1 (L)	2.3 ± 0.9	2.4 ± 0.6	2.2 ± 0.8	2.8 ± 0.5ab
FEV1%	76.8 ± 11.6	77.5 ± 16.3	75.6 ± 14.5	84.6 ± 12.7ab
PEF (L/S)	4.4 ± 1.5	4.8 ± 1.7	4.6 ± 1.2	5.9 ± 1.6ab
PEF%	74.8 ± 19.6	75. ± 16.3	70.5 ± 20.4	85.1 ± 23.1ab
PC20-FEV1 (g/L)	0.31 ± 0.11	0.28 ± 0.16	0.33 ± 0.14	0.84 ± 0.22ab

^aP < 0.05 vs. group A after therapy, the t values were 2.34, 2.59, 2.31, 2.55, 2.49, 2.26, 2.63, 2.22, and 2.68, respectively.

^bP < 0.01 vs. group B before therapy, the t values were 3.93, 4.16, 3.87, 4.04, 3.95, 3.62, 4.46, 3.98, and 4.33, respectively.