Lin LW, Lin XD, He YM, Gao SD, Xue ES. Experimental study on ultrasound-guided intratumoral injection of “Star-99” in treatment of hepatocellular carcinoma of nude mice. World J Gastroenterol 2003; 9(4): 701-705 [PMID: 12679914 DOI: 10.3748/wjg.v9.i4.701]
Corresponding Author of This Article
Dr. Li-Wu Lin, Department of Ultrasound, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China. lxdghl@163.net
Article-Type of This Article
Liver Cancer
Open-Access Policy of This Article
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World J Gastroenterol. Apr 15, 2003; 9(4): 701-705 Published online Apr 15, 2003. doi: 10.3748/wjg.v9.i4.701
Table 1 Comparison of the growth index of Star-99, ethanol and saline groups
Groups
n
x-
SD
P
Star-99 (A)
14
0.076
± 0.024
A, B > 0.05
Ethanol (B)
7
0.082
± 0.028
B, C < 0.01
Saline (C)
7
4.654
± 1.283
A, C < 0.01
Table 2 Comparison of the serum levels of IL-2 and TNF-α after treatment in the three groups
Groups
n
IL-2 (ng/mL)
TNF-α (ng/mL)
P
Star-99 (A)
14
6.63 ± 1.39
3.98 ± 1.05
A:B < 0.05
Ethanol (B)
7
4.22 ± 1.23
2.95 ± 1.01
A:C < 0.05
Saline (C)
7
4.51 ± 0.84
2.84 ± 1.05
B:C > 0.05
Table 3 Comparison of the apoptotic index of Star-99, ethanol and saline groups after treatment
Groups
n
AI (%)
P
Star-99 (A)
14
48.98 ± 5.09
A:B < 0.01
Ethanol (B)
7
11.95 ± 2.24
B:C > 0.05
Saline (C)
7
10.48 ± 3.85
A:C < 0.01
Table 4 Comparison of the appearance rates of the hereroploidy and apoptosis peak after treatment in the three groups
Groups
n
Hereroploidy peak (%)
P
Apoptosis peak (%)
P
Star-99 (A)
14
7.1 (1/14)
A:B > 0.05
92.9 (13/14)
A:B < 0.01
Ethanol (B)
7
0.0 (0/7)
B:C < 0.05
14.3 (1/7)
B:C > 0.05
Saline (C)
7
57.1 (4/7)
A:C < 0.05
0.0 (0/7)
A:C < 0.01
Citation: Lin LW, Lin XD, He YM, Gao SD, Xue ES. Experimental study on ultrasound-guided intratumoral injection of “Star-99” in treatment of hepatocellular carcinoma of nude mice. World J Gastroenterol 2003; 9(4): 701-705