Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma

Table 1 The relationship between COX-2, MVD and patho-logical features of gastric carcinoma

Pathological characteristics	Positive	MVD	Total
	COX-2 (%)	-x ± s
Tumor size
< 5 cm	15 (75.0)	60.64 ± 18.55	20
≥ 5 cm	20 (80.0)	55.68 ± 17.98	25
Depth of invasion
Invading serosa	29 (87.88)a	57.01 ± 18.79c	33
Noinvasion to serosa	6 (50.0)	42.35 ± 14.65	12
Degree of differentiation
Well differentiated	12 (80.0)	52.45 ± 17.67	30
Poorly differentiated	23 (76.67)	57.32 ± 18.20	15
Lymph-node metastasis
Positive	31 (86.11)b	58.60 ± 18.24d	36
negative	4 (44.44)	43.54 ± 15.05	9

Note: Well differentiated cancer cells include highly and moderately differentiated ones: poorly differentiated cancer cells include poorly differentidted and undifferediated ones.

^aP < 0.05 (Χ² = 5.23), vs the rate of COX-2 expression in gastric carcinomas not invading serosa;

^bP < 0.05 (Χ² = 5.08), vs the rate of COX-2 expression in gastric carcinoma without lymoph-node metastasis;

^cP < 0.05 (t = 2.44), vs MVD in gastric carcinomas not invading serosa;

^dP < 0.05 (t = 2.28), vs MVD in gastric carcinomas without lymph-node metastasis.