Relationship between clinical and pathologic findings in patients with chronic liver diseases

Table 1 Relationship between clinical manifestations and pathological grading and staging of liver tissues

Groups	Symptom score + physical signs	n	Inflammatory grading ( G ) (%)				Fibrosis staging (s) (%)
			1	2	3	4	0		1	2	3	4
1	0~1+ no hepatomegaly and splenomegaly	15	46.7	40	13.3	0	33.3		26.7	40	0	0
2	0~1+ hepatomegaly and splenomegaly	14	28.6	28.6	28.6	14.3	7.1		35.7	28.6	14.3	14.3
3	~3+no hepatomegaly and splenomegaly	28	42.9	53.6	3.5	0	14.3		50	35.7	0	0
4	2~3 +hepatomegaly and splenomegaly	42	30.9	26.2	28.5	16.7	9.5		23.8	40.5	16.7	9.5
5	4+ no hepatomegaly and splenomegaly	32	43.7	25	15.6	15.6	12.5		34.3	25	15.6	12.5
6	4+ hepatomegaly and splenomegaly	69	23.3	21.7	34.8	15.9	2.9		29	29	15.9	23.2
				P < 0.01						P < 0.01

Table 2 Relationship between biochemical parameters and inflammatory grading and fibrosis staging

Parameters	Inflammatory (G) (%)						Fibrosis staging (s) (%)
	1~2	1~3	1~4	2~3	2~4	3~4	0~1	0~2	0~3	0~4	1~2	1~3	1~4	2~3	2~4	3~4
RBC			b		b	b				a			a		a	a
PLT			b		b	b
AST		b	b	a	b
ALT
AST/ALT
GGTa	a	b	b	b			b	b	b	b	b	b
A				b		b				b			b		b	b
A/G				b		b				b			b		b	b
HA	b	b	b	b	b	b			b	b	b	b	b		b	b
LN
7S-IV		a	b	a	b					a			a		a
PIIINP			b		b
AFP	b	b	b	b	b	b		b	b		b	b			b
PT

^aP < 0.05, ^bP < 0.01.

Table 3 Serologic parameters for diagnosing liver fibrosis and cirrhosis

Parameters	Fibrosis (S0/S1~4)			Cirrhosis (S1~3/S4)
	Specificity (%)	Sensitivity (%)	Accuracy (%)	Specificity (%)	Sensitivity (%)	Accuracy (%)
HA	94.44	38.26	43.50	90.0	60.0	85.71
PIIINP	16.67	77.71	72.0	78.0	24.0	70.28
LN	55.26	50.29	50.10	54.0	52.0	53.71
7S-IV	50.22	24.67	51.0	93.29	24.0	89.08

Table 4 Serologic parameters for diagnosing liver fibrosis and cirrhosis

Parameters	Fibrosis (S0/S1~4)			Cirrhosis (S1~3/S4)
	Specificity (%)	Sensitivity (%)	Accuracy (%)	Specificity (%)	Sensitivity (%)	Accuracy (%)
HA+7S-IV	88.89	37.93	42.50	89.93	60.0	85.63
HA+PIIINP	88.89	42.86	47.10	90.0	60.0	85.71
HA+7S-IV+	88.89	47.13	51.04	89.93	64.0	86.21
PIIINP+LN
HA+TIMP	92.86	38.28	43.67	90.27	60.0	86.72
PGA+HA	60.0	60.44	60.40	89.41	66.67	87.91
PGAA+HA	70.0	62.64	63.67	89.41	66.67	87.91
PGA+7S-IV	61.12	50.22	50.31	90.59	33.33	86.80
PGAA+7S-IV	60.0	48.22	50.67	92.94	33.33	89.0