Copyright
©The Author(s) 2003.
World J Gastroenterol. Dec 15, 2003; 9(12): 2776-2781
Published online Dec 15, 2003. doi: 10.3748/wjg.v9.i12.2776
Published online Dec 15, 2003. doi: 10.3748/wjg.v9.i12.2776
Type of mucosal damages | Group of TBI |
Shedding of epithelial cells from the top of villi | 3 and 12 hours |
Epithelial cell necrosis and disarrangement of villi | 24 and 72 hours |
Focal mucosa ulcer with exposure of submucosal interstitium | 72 hours |
Fusion of adjacent villi into piece | 72 hours and 7 days |
Dilation of central chyle duct | 72 hours and 7 days |
Inflammatory cell infiltration in intestinal wall | 72 hours and 7 days |
Mucosal atrophy | 7 days |
Vascular dilation, congestion and edema in villous interstitium and lamina propria | 3 hours throughout 7 days |
Groups | Villous height (µm) | Villous diameter (µm) | Crypt depth (µm) | Surface area (mm2) |
Control | 229.2 ± 18.1 | 37.4 ± 5.5 | 79.3 ± 9.6 | 0.0259 ± 0.0048 |
TBI 3 hours | 219.5 ± 21.2 | 37.6 ± 6.1 | 78.9 ± 9.4 | 0.0258 ± 0.0035 |
TBI 12 hours | 214.5 ± 22.5 | 35.6 ± 3.1 | 74.0 ± 6.9 | 0.0241 ± 0.0037 |
TBI 24 hours | 189.2 ± 13.6b | 32.7 ± 3.2 | 67.0 ± 7.6bc | 0.0195 ± 0.0012bc |
TBI 72 hours | 150.8 ± 10.4bc | 32.1 ± 4.2 | 34.8 ± 5.6bc | 0.0151 ± 0.0010bc |
TBI 7 days | 136.7 ± 15.7bc | 30.8 ± 5.8 | 38.3 ± 6.1bc | 0.0130 ± 0.0015bc |
- Citation: Hang CH, Shi JX, Li JS, Wu W, Yin HX. Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats. World J Gastroenterol 2003; 9(12): 2776-2781
- URL: https://www.wjgnet.com/1007-9327/full/v9/i12/2776.htm
- DOI: https://dx.doi.org/10.3748/wjg.v9.i12.2776