Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters

Table 1 Pathological diagnostic results of 200 liver biopsy samples

Staging of fibrosis	Grading of inflammation					value
	1	2	3	4	Total	χ²-value	P-value
0	18	2	0	0	20	278.3	1E-04
1	42	22	0	0	64
2	6	33	26	0	64
3	9	2	19	4	25
4	0	0	3	23	26
Total	66	59	48	27	200

Table 2 Relationship between serum biochemical parameters and grading of inflammation

Parameter	Comparision among groups of inflammation grading
	1-2	1-3	1-4	2-3	2-4	3-4
RBC			b		b	b
PLT			b		b	b
AST		b	b	a	b
GGT	a	b	b	b	b
Albumin			b		b	b
Albumin/globulin			b		b	b
ALP			b		b
AFP	b	b	b	b	b	b
HA	b	b	b	b	b	b
PIIINP			b		b
7S-IV		a	b	a	b
TIMP-1		a	a
α-MA			b		a
NK			b		a	a
IgG			b		b	b
IgG + IgA + IgM			b		b	b

^aP < 0.05, ^bP < 0.01.

Table 3 Relationship between serum biochemical parameters and staging of liver fibrosis

Parameter	Comparision among groups of liver fibrosis staging
	0-1	0-2	0-3	0-4	1-2	1-3	1-4	2-3	2-4	3-4
RBC				a			a		a	a
GGT		b	b	b	b	b	b
Albumin				b			b		b	b
Albumin/globulin				b			b		b	b
ALP				b			a
AFP			b	b		b	b		b
HA		b	b	b	b	b	b		b	b
7S-IV				a			a		a
TIMP-1			a	b		a	a
α-MA				a			b		a
TGFβ-1	a	a	a	a
IgG				b			b		b	b
IgG + IgA + IgM				b			b		b	b

^aP < 0.05, ^bP < 0.01.

Table 4 Comparison between parameters of ultrasonic 2-D and color Doppler flow image and groups of inflammation grading

Parameter	Comparision among groups of inflammation grading
	1-2	1-3	1-4	2-3	2-4	3-4
Inner diameter of left portal vein		a
Inner diameter of middle liver vein			a		a
Inner diameter of right liver vein			b		a
Thickness of gallbladder wall		a	b	a	b
Shape of gallbladder			b		b
Vertical diameter of spleen		a	b	a	b
Thickness of spleen		a	b	a	b
Diameter of spleen vein			b		a
Thickening of the light dots in liver substance			b		b
Movement degree along with breath			b		a
Movement degree along with heart beat			b		a
Blood stream velocity in constriction phase of liver artery		a
Blood stream velocity in dilation phase of liver artery			a

^aP < 0.05, ^bP < 0.01.

Table 5 Comparison between parameters of ultrasonic 2-D and color Doppler flow image and groups of liver fibrosis staging

Parameter	Comparision among groups of liver fibrosis staging
	0-1	0-2	0-3	0-4	1-2	1-3	1-4	2-3	2-4	3-4
Thickness of liver capsule				a
Maximum oblique diameter of right liver	a	b	b	b
Tube diameter of portal vein trunk		a		a
Inner diameter of left portal vein	a	b	b	a
Inner diameter of right portal veinInner diameter of right portal vein	a	a	a	a
Thickness of gallbladder wall				b			b		a	a
Shape of gallblader				b			a		a	a
Diameter of splenic vein				b			a			a
Vertical diameter of spleen			a	b			b		a
Thickness of spleen				a
Thickening of the light dots in liver substance		a		b			a
Movement degree along with breath				b			a
Movement degree along with heart beat									b	a
Parameter of blood flow of portal vein per minute	a	a	a	a

^aP < 0.05, ^bP < 0.01.