Lu LG, Zeng MD, Wan MB, Li CZ, Mao YM, Li JQ, Qiu DK, Cao AP, Ye J, Cai X, Chen CW, Wang JY, Wu SM, Zhu JS, Zhou XQ. Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters. World J Gastroenterol 2003; 9(11): 2574-2578 [PMID: 14606100 DOI: 10.3748/wjg.v9.i11.2574]
Corresponding Author of This Article
Lun-Gen Lu, MD, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China. lulungen@online.sh.cn
Article-Type of This Article
Clinical Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 15, 2003; 9(11): 2574-2578 Published online Nov 15, 2003. doi: 10.3748/wjg.v9.i11.2574
Table 1 Pathological diagnostic results of 200 liver biopsy samples
Staging of fibrosis
Grading of inflammation
value
1
2
3
4
Total
χ²-value
P-value
0
18
2
0
0
20
278.3
1E-04
1
42
22
0
0
64
2
6
33
26
0
64
3
9
2
19
4
25
4
0
0
3
23
26
Total
66
59
48
27
200
Table 2 Relationship between serum biochemical parameters and grading of inflammation
Parameter
Comparision among groups of inflammation grading
1-2
1-3
1-4
2-3
2-4
3-4
RBC
b
b
b
PLT
b
b
b
AST
b
b
a
b
GGT
a
b
b
b
b
Albumin
b
b
b
Albumin/globulin
b
b
b
ALP
b
b
AFP
b
b
b
b
b
b
HA
b
b
b
b
b
b
PIIINP
b
b
7S-IV
a
b
a
b
TIMP-1
a
a
α-MA
b
a
NK
b
a
a
IgG
b
b
b
IgG + IgA + IgM
b
b
b
Table 3 Relationship between serum biochemical parameters and staging of liver fibrosis
Parameter
Comparision among groups of liver fibrosis staging
0-1
0-2
0-3
0-4
1-2
1-3
1-4
2-3
2-4
3-4
RBC
a
a
a
a
GGT
b
b
b
b
b
b
Albumin
b
b
b
b
Albumin/globulin
b
b
b
b
ALP
b
a
AFP
b
b
b
b
b
HA
b
b
b
b
b
b
b
b
7S-IV
a
a
a
TIMP-1
a
b
a
a
α-MA
a
b
a
TGFβ-1
a
a
a
a
IgG
b
b
b
b
IgG + IgA + IgM
b
b
b
b
Table 4 Comparison between parameters of ultrasonic 2-D and color Doppler flow image and groups of inflammation grading
Parameter
Comparision among groups of inflammation grading
1-2
1-3
1-4
2-3
2-4
3-4
Inner diameter of left portal vein
a
Inner diameter of middle liver vein
a
a
Inner diameter of right liver vein
b
a
Thickness of gallbladder wall
a
b
a
b
Shape of gallbladder
b
b
Vertical diameter of spleen
a
b
a
b
Thickness of spleen
a
b
a
b
Diameter of spleen vein
b
a
Thickening of the light dots in liver substance
b
b
Movement degree along with breath
b
a
Movement degree along with heart beat
b
a
Blood stream velocity in constriction phase of liver artery
a
Blood stream velocity in dilation phase of liver artery
a
Table 5 Comparison between parameters of ultrasonic 2-D and color Doppler flow image and groups of liver fibrosis staging
Parameter
Comparision among groups of liver fibrosis staging
0-1
0-2
0-3
0-4
1-2
1-3
1-4
2-3
2-4
3-4
Thickness of liver capsule
a
Maximum oblique diameter of right liver
a
b
b
b
Tube diameter of portal vein trunk
a
a
Inner diameter of left portal vein
a
b
b
a
Inner diameter of right portal veinInner diameter of right portal vein
a
a
a
a
Thickness of gallbladder wall
b
b
a
a
Shape of gallblader
b
a
a
a
Diameter of splenic vein
b
a
a
Vertical diameter of spleen
a
b
b
a
Thickness of spleen
a
Thickening of the light dots in liver substance
a
b
a
Movement degree along with breath
b
a
Movement degree along with heart beat
b
a
Parameter of blood flow of portal vein per minute
a
a
a
a
Citation: Lu LG, Zeng MD, Wan MB, Li CZ, Mao YM, Li JQ, Qiu DK, Cao AP, Ye J, Cai X, Chen CW, Wang JY, Wu SM, Zhu JS, Zhou XQ. Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters. World J Gastroenterol 2003; 9(11): 2574-2578