Organ failure associated with severe acute pancreatitis

Table 1 Characteristics of 74 patients with or without organ failure

	Organ failure (n = 47)	No organ failure (n = 27)	Sig.
Age (Y)	4815	4915	NS
Gender (M/F)	26/21	14/13	NS
Etiology
Gallstones	21	11	NS
Non-gallstones	26	16
APACHE II scores	29 ± 7	23 ± 3	< 0.001
Mortality (%)	12/47 (25.5)	0	< 0.05

Table 2 Number of patients with organ failure in 74 patients

Organ failure	Morbidity (%)	Mortality (%)
Multiple organ failure	20 (27.0%)	9 (45%)
Specific single organ failure
Pulmonary failure	17 (23.0%)	3 (17.6%)
Renal failure	0	0
Cardiovascular failure	0	0
Hepatic failure	7 (9.4%)	0
Neurologic failure	0	0
Gastrointestinal failure	3 (4.1%)	0

Table 3 Frequency of organ failure in 74 patients

Organ failure	No. organ failure	Frequency (%)
Multiple organ failure	20	27.0
Pulmonary failure	34	45.9
Renal failure	12	16.2
Cardiovascular failure	13	17.6
Hepatic failure	14	18.9
Neurologic failure	4	5.4
Gastrointestinal failure	8	10.8

Table 4 Relationship between infected versus sterile necrosis and organ failure in 74 patients

	Organ failure (%)	No. organ failure (%)
Sterile necrosis	31 (66.0)	16 (34.0)
Infected necrosis	16 (59.3)	11 (40.7)

Note: χ² = 0.3320, P > 0.05.

Table 5 Relationship between amount of necrosis and organ failure in 74 patients

Amount of necrosis (%)	Organ failure (n = 47)	No. organ failure (n = 27)
< 33%	21 (55.3%)	17 (44.7%)
33%-50%	11 (64.7%)	6 (35.3%)
> 50%	15 (78.9%)	4 (21.1%)

Note: χ² = 3.0784, P > 0.05.

Table 6 Relationship between infected versus sterile necrosis and single organ failure in 74 patients

Organ failure (%)	Sterile necrosis (n = 47)	Infected necrosis (n = 27)	χ²	Sig.
Multiple organ failure	13 (27.7%)	7 (25.9%)	0.0261	NS
Pulmonary failure	24 (51.1%)	10 (37.0%)	1.3585	NS
Renal failure	6 (12.8%)	6 (22.2%)	1.1287	NS
Cardiovascular failure	10 (21.3%)	3 (11.1%)	1.2237	NS
Hepatic failure	7 (14.9%)	7 (25.9%)	1.3607	NS
Neurologic failure	4 (8.5%)	0		NSa
Gastrointestinal failure	4 (8.5%)	4 (14.8%)	0.7068	NS

^a: Fisher’s exact probabilities test.

Table 7 Relationship between hospital death and organ failure in 74 patients

Organ failure	Survivor (n = 62)	Nonsurvivor (n = 12)	χ²	P value
Multiple organ failure	11 (17.7%)	9 (75%)	16.7130	< 0.005
Pulmonary failure	22 (35.5%)	12 (100%)	16.8501	< 0.005
Renal failure	8 (12.9%)	4 (33.3%)	1.7680	NS
Cardiovascular failure	8 (12.9%)	5 (41.7%)	3.9295	< 0.05
Hepatic failure	11 (17.7%)	3 (25%)	0.0342	NS
Neurologic failure	0	4 (33.3%)		NSa
Gastrointestinal failure	4 (6.5%)	4 (33.3%)	5.0050	< 0.05

^a: Fisher’s exact probabilities test.