Expression of p27, cyclin E and cyclin A in hepatocellular carcinoma and its clinical significance

Table 1 Expression of p27 and pathological features (¯x ± s)

Groups		n	p27 LI (¯x ± s)		P
Histological grade		I + II	52.80 ± 11.36	t = 5.17	< 0.001
	III + IV	19	34.46 ± 12.29
Tumor size (d)	≤ 5 cm	9	53.28 ± 15.17	F = 5.934	< 0.005
	5 < d ≤ 10 cm	19	49.50 ± 10.96
	> 10 cm	17	37.59 ± 13.12
Envelope	Full	26	48.82 ± 13.35	t = 1.76	> 0.05
	Rupture	19	41.54 ± 14.15
Tumor thrombi	+	13	36.83 ± 12.74	t = 2.77	< 0.01
	-	32	49.16 ± 13.41
Metastasis	Positive	11	35.52 ± 11.70	t = 3.02	< 0.05
	Negative	34	49.22 ± 13.43
Number	< 2	33	47.65 ± 15.08	t = 1.41	> 0.05
	≥ 2	12	40.98 ± 10.52
Non-invasive and non- metastatic group			51.44 ± 14.10	t = 2.48	< 0.02
Invasive and metastatic group			41.42 ± 12.86

Table 2 Expression of cyclin E, cyclin A and pathological features

Group		n	Cyclin E		Cyclin A
			+	χ²/P	+	χ²/P
Histological grade	I + II	26	5 (19.23%)	7.16/< 0.05	8 (30.77%)	6.25/< 0.05
	III + IV	19	11 (57.89%)		13 (68.42%)
Tumor size (d)	≤ 5 cm	9	1 (11.11%)	1.58/> 0.05	5 (55.56%)	1.29/> 0.05
	5 < d ≤ 10 cm	19	7 (36.84%)		7 (36.84%)
	> 10 cm	17	8 (47.06%)		9 (52.94%)
Envelope	Full	26	7 (26.92%)	2.00/> 0.05	10 (38.46%)	1.67/> 0.05
	Rupture	19	9 (47.37%)		11 (57.89%)
Tumor thrombi	+	13	8 (61.54%)	5.38/< 0.01	10 (76.92%)	6.72/< 0.01
	-	32	8 (25.00%)		11 (34.38%)
Metastasis	Positive	11	6 (54.55%)	1.32/> 0.05	9 (81.82%)	7.23/< 0.01
	Negative	34	10 (29.41%)		12 (35.29%)
Number	< 2	33	9 (27.28%)	2.47/> 0.05	12 (36.36%)	5.76/< 0.05
	≥ 2	12	7 (58.33%)		9 (75.00%)
Non-invasive and non- metastatic group			4 (20.00%)	3.86/< 0.05	4 (20.00%)	9.95/< 0.01
Invasive and metastatic group			12 (48.00%)		17 (68.00%)

Table 3 Relationship between expressions of cyclin E and cyclin A

		Cyclin A		P
		+	-
cyclin E	+	11	5	< 0.05
	-	10	19