Significant factors associated with fatal outcome in emergency open surgery for perforated peptic ulcer

Table 1 Associated diseases in study group

Cardiovascular disease	27
Diabetes mellitus	20
Chronic obstructive pulmonary disease	19
Impaired liver function	8
Renal failure	7
Coagulation disorders	6
Cerebrovascular disease	4
Neurological disease (others)	3
Malignancy	2
Thyroid disease	1
Gallstones	1
Acute pancreatitis	1
Total	99

Table 2 Postoperative complications

General
Cardiac	7
Respiratory	7
Sepsis	7
Renal	5
Mental disorders	2
Ictus	1
Deep venous thrombosis	1
Total	30
Abdominal
Abscess	6
Bleeding	2
Stenosis	2
Total	10
Wound infections	8
Total	48

Table 3 Analysis of factors associated with mortality in 149 patients undergoing surgery for perforated peptic ulcer

	n	Mortality (%)	P value
Male:Female	110:39	3.6 vs 5.1	NS
Age (< 65: > 65 years)	63:86	1.6 vs 5.8	NS
Previous ulcer history (yes:no)	53:96	5.7 vs 3.1	NS
Associated disease (yes:no)	79:70	7.6 vs 0.0	0.02
Delayed operations (yes:no)	41:108	9.8 vs 1.9	0.04
Site (duodenal:gastric)	126:23	3.1 vs 8.7	NS
Operation type	120:29	2.5 vs 10.3	NS
(non definitive:definitive)
Shock on admission (yes:no)*	9:140	55.6 vs 0.7	0.0001
Postop. general	30:119	6.7 vs 3.4	NS
complications (yes:no)
Postop. abdominal	10:139	50.0 vs 0.7	0.0001
complications (yes:no)*
Postoperative wound	8:141	37.5 vs 2.1	0.0001
infections (yes:no)*

Data analyzed by χ² test and *Fisher’s exact test.