Effect of ischemic preconditioning on P-selectin expression in hepatocytes of rats with cirrhotic ischemia-reperfusion injury

doi:10.3748/wjg.v9.i10.2289

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Oct 15, 2003 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 15, 2003; 9(10): 2289-2292
Published online Oct 15, 2003. doi: 10.3748/wjg.v9.i10.2289

Table 1 ATP, ADP, AMP and EC levels in liver after ischemia and reperfusion (U/L)

Groups	n	After ischemia				After reperfusion
Groups	n	ATP	ADP	AMP	EC	ATP	ADP	AMP	EC
SO	8	5.4 ± 1.3	3.1 ± 0.8	1.0 ± 0.2	0.7 ± 0.0	5.5 ± 0.8	3.2 ± 1.0	1.0 ± 0.1	0.7 ± 0.0
I/R	8	0.5 ± 0.2^b	2.3 ± 0.6^a	3.5 ± 1.0^b	0.3 ± 0.0^b	1.5 ± 0.6^b	2.3 ± 1.2	2.6 ± 1.3^a	0.4 ± 0.1^b
IPC	8	0.5 ± 0.1^b	2.1 ± 0.5^a	3.6 ± 1.5^b	0.3 ± 0.1^b	4.1 ± 1.6^a^c	2.3 ± 0.8	1.9 ± 0.9	0.6 ± 0.1^a^c
APC	8	0.5 ± 0.1^b	2.2 ± 0.5^a	3.4 ± 0.7^b	0.3 ± 0.0^b	4.0 ± 1.6^a^c	2.5 ± 1.1	2.2 ± 1.2^a	0.6 ± 0.1^a^c
NPC	8	0.5 ± 0.2^b	2.0 ± 0.7^a	3.3 ± 0.6^b	0.3 ± 0.0^b	2.3 ± 1.6^b	2.2 ± 0.9^a	3.2 ± 1.1^b	0.4 ± 0.1^b

^aP < 0.05,

^bP < 0.01, vs SO group;

^cP < 0.01, vs I/R group.

Table 2 Results of ALT, AST and LDH in serum after reperfusion (U/L)

Groups	Cases	ALT	AST	LDH
SO	8	300.5 ± 159.2	551.1 ± 84.7	4612.3 ± 1042.8
I/R	8	2218.8 ± 825.3^a	3043.8 ± 1198.9^a	13762.5 ± 5371.9^a
IPC	8	568.8 ± 214.6^b	1315.0 ± 958.9^b	6266.3 ± 2425.5^b
APC	8	508.8 ± 142.8^b	1108.8 ± 637.2^b	5355.0 ± 1237.9^b
NPC	8	2091.3 ± 684.6^a	3083.8 ± 844.5^a	11361.3 ± 4211.8^a

^aP < 0.01, vs SO group;

^bP < 0.01, vs I/R group.

Table 3 Results of bile output and leukocyte count in ischemic hepatic lobe

Groups	Cases	Bile output (mL/g liver)	Leukocyte count (piece/HP)
SO	8	0.15 ± 0.02	181.38 ± 59.23
I/R	8	0.07 ± 0.03^a	442.38 ± 94.10^a
IPC	8	0.10 ± 0.03^a^b	353.00 ± 84.11b^a
APC	8	0.10 ± 0.02^a^b	347.75 ± 51.53^b^a
NPC	8	0.07 ± 0.01^a	407.88 ± 90.40^a

^aP < 0.01, vs SO group;

^bP < 0.05, vs I/R group.

Table 4 Expression of P-selectin in liver tissues

Groups	Cases	Grade			Average rank
Groups	Cases	(+)	(++)	(+++)	Average rank
SO	8	7	1	0	10.69
I/R	8	0	5	3	30.50^a
IPC	8	5	3	0	15.06^b
APC	8	4	4	0	17.25^b
NPC	8	0	6	2	29.00^a

^aP < 0.01, vs SO group;

^bP < 0.05, vs I/R group.

Citation: Cheng XD, Jiang XC, Liu YB, Peng CH, Xu B, Peng SY. Effect of ischemic preconditioning on P-selectin expression in hepatocytes of rats with cirrhotic ischemia-reperfusion injury. World J Gastroenterol 2003; 9(10): 2289-2292
URL: https://www.wjgnet.com/1007-9327/full/v9/i10/2289.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i10.2289