Detection of soluble TRAIL in HBV infected patients and its clinical implications

Table 1 Statistical analysis of the relevance of expression of sTRAIL and clinical staging of hepatitis B

	n	sTRAIL( × 10-9μg/mL)
HBV carriers	8	876.88 ± 369.59
Chronic hepatitis	30	1494.97 ± 533.24
Mild chronic hepatitis	9	1138.90 ± 424.90
Moderate chronic hepatitis	12	1558.65 ± 489.87a
Severe chronic hepatitis	9	1812.78 ± 499.99b
HBV infectious related cirrhosis	11	1375.00 ± 526.08c
HBV related infectious liver cancer	3	1561.00 ± 449.56d

^aP < 0.01 vs mild chronic hepatitis group;

^bP < 0.001 vs mild chronic hepatitis group;

^cP < 0.05 vs severe chronic hepatitis group;

^dP < 0.05 vs severe chronic hepatitis group

Table 2 Analysis of corelation between the expression of sTRAIL and clinical indices of hepatitis B

	sTRAIL	Clinical indices		Correlativity coeffficient
HBV carrier	876.88 ± 369.59	ALT	28.38 ± 5.09
		Tbil	17.73 ± 3.34
		ALB	39.5 ± 1.20
Chronic hepatitis	1494.97 ± 533.24	ALT	173.61 ± 135.32	r = 0.496(P < 0.01)
		Tbil	66.79 ± 61.73
		ALB	32.95 ± 5.86	r = -0.392(P < 0.05)
HBV infectious related cirrhosis	1375.00 ± 526.08	ALT	150.36 ± 132.72
		Tbil	82.83 ± 118.00
		ALB	34.01 ± 5.79
HBV infectious related liver cancer	1561 ± 449.56	ALT	85.67 ± 48.76
		Tbil	58.81 ± 24.43
		ALB	36.63 ± 10.07

Table 3 Analysis of correlation between the expression of HBsAg and that of sTRAIL

Group divided by S/N	n	Expression of HBsAg(S/N)	Expression of sTRAIL in peripheral blood ( × 10-9μg/mL)
< 2.1(-)	2	0.5 ± 0.7	1852.50 ± 123.74
> 2.1 and < 10(+)	0
> 10 and < 30(++)	0
> 30 and < 50(+++)	4	43.25 ± 3.78	1693.75 ± 547.76
> 50(++++)	46	61.48 ± 5.19	1330.30 ± 537.80

Table 4 Analysis of the correlation between Expression of HBeAg and that of sTRAIL

Group divided by S/N	cases	The expression of HBeAg(S/N)	Expression of sTRAIL in peripheral blood ( × 10-9μg/mL)
< 2.1(-)	14	0.86 ± 0.51	1166.81 ± 448.84
> 2.1 and < 10(+)	9	5.47 ± 2.88	1088.33 ± 528.27a
> 10 and < 30(++)	19	20.79 ± 5.39	1590.26 ± 474.81ab
> 30 and < 50(+++)	4	36.06 ± 4.82	1655.00 ± 534.48a
> 50(++++)	6	54.69 ± 4.49	1730.83 ± 652.64bc

^aP < 0.05 vs the negative group;

^bP < 0.01 vs the negative group;

^cP < 0.05 vs the mildly positive group(+)