Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma

Table 1 Univariate analysis of the clinicopathologic factors for the survival of 86 patients with bile duct carcinoma

Factors	No. of patients	P value
Sex		0.90
Male	51
Female	35
Age (yrs)		0.33
< 50	29
≥ 50	57	0.15
Location of tumor
Upper	40
Middle	13
Lower	33
Size of tumor		0.21
< 2 cm	11
2 – 4 cm	62
> 4 cm	13
Macroscopic type of lesions		0.43
Papillary	17
Nodular	32
Infiltrating	37
Histological type of lesion		0.02
Papillary adenocarcinoma	7
Well differentiated adenocarcinoma	27
Moderately differentiated adenocarcinoma	36
Poorly differentiated adenocarcinoma	14
Adenosquamous cell carcinoma	2
Hepatic metastasis		0.88
Present	2
Absent	84
Lymph node metastasis		0.02
Present	37
Absent	49
Hepatic invasion		0.36
Present	29
Absent	57
Pancreatic invasion		0.004
Present	21
Absent	65
Duodenal invasion		0.005
Present	14
Absent	72
Resected margin of the bile duct		0.03
Present	19
Absent	67
Perineural invasion	0.01
Present	65
Absent	21
Vascular invasion		0.04
Present	17
Absent	69
Depth of cancer invasion		0.04
Invasion limited to fibromuscular layer	9
Invasion limited to adventitia and subserosal layer	59
Invasion to and beyond the serosal exposure	18

Table 2 Relative values of three prognostic variables derived from Cox stepwise proportional hazards model

Variables	β	SE	Sig (P)	Exp (B)	95%CI for Exp (B)
Pancreatic invasion	0.226	0.084	0.007b	1.254	(1.064-1.479)
Perineural invasion	0.691	0.236	0.012a	2.408	(1.221-4.753)
Lymph node metastasis	0.894	0.489	0.023a	2.762	(1.164-6.557)

^aP < 0.05,

^bP < 0.01, vs control