Hepatoprotective role of ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice

doi:10.3748/wjg.v8.i4.728

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 8, Issue 4

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5667)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-3) series.

Item

Count

PDF

652

HTML

4531

Figures (1-2)

222

Tables (1-3)

262

Sum=5667

Aug 15, 2002 (publication date) through Dec 24, 2024

Times Cited of This Article

Times Cited (71)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Aug 15, 2002; 8(4): 728-733
Published online Aug 15, 2002. doi: 10.3748/wjg.v8.i4.728

Table 1 Effect of Ganoderma lucidum polysaccharide (GLP) on the weight of liver and the activity of serum alanine transaminase (ALT) in BCG-induced immune hepatic injury in mice (¯x ± s)

Group	Liver weight (g)	ALT (U·L^-1)
Control	0.99 ± 0.16	22.03 ± 10.99
BCG (125 mg·kg^-1)	1.79 ± 0.24^b	245.18 ± 41.03^b
BCG (125 mg·kg^-1) + LPS (125 μg·kg^-1)	1.84 ± 0.14^b	285.88 ± 23.81^b^c
BCG (125 mg·kg^-1) + GLP (25 mg·kg^-1)	1.78 ± 0.20^b	236.86 ± 27.94^b
BCG (125 mg·kg^-1) + GLP (50 mg·kg^-1)	1.57 ± 0.18^b^c	189.81 ± 43.99^b^c
BCG (125 mg·kg^-1) + GLP (100 mg·kg^-1)	1.28 ± 0.20^b^d	178.78 ± 13.16^b^d
BCG (125 mg·kg^-1) + GLP (200 mg·kg^-1)	1.41 ± 0.43^b^c	208.18 ± 27.93^b^c

^aP < 0.05,

^bP < 0.01 compared with control.

^cP < 0.05,

^dP < 0.01 compared with BCG-pretreated group. n = 9 mice (liver weight groups) or 10 mice (ALT groups).

Table 2 Effect of Ganoderma lucidum polysaccharide (GLP) on the granuloma formation (numbers/microscopic view) in BCG -pretrested mice hepatic histological slides. (¯x ± s)

Croup	Granulomas
Control	0
BCG (125 mg·kg^-1)	64.67 ± 4.97^b
BCG (125 mg·kg^-1) + LPS (125 μg·kg^-1)	54.40 ± 4.93^b
BCG (125 mg·kg^-1) + GLP (50 mg·kg^-1)	60.00 ± 4.24^b
BCG (125 mg·kg^-1) + GLP (100 mg·kg^-1)	4.00 ± 1.22^b^d
BCG (125 mg·kg^-1) + GLP (200 mg·kg^-1)	36.80 ± 5.81^b^d

^aP < 0.05,

^bP < 0.01 compared with control. ^cP < 0.05,

^dP < 0.01 compared with BCG-pretreated group. n = 5 microscopic views.

Table 3 Effects of Ganoderma lucidum polysaccharide (GLP) on the alanine transaminase (ALT) activity and nitrite (NO₂^-) production induced by BCG-prestimulating in the presence or absence of cytokines mixture (CM) in primary cultured mice hepatocytes in vitro (¯x ± s)

Group	ALT (U·L^-1)	NO₂^- (μmol·L^-1)
Control	11.52 ± 1.41^b	1.41 ± 0.72^a
BCG	17.87 ± 3.41	3.52 ± 1.72
BCG + GLP (50 mg·k^-1)	21.30 ± 2.87	3.95 ± 1.27
BCG + GLP (200 mg·k^-1)	18.03 ± 2.24	3.24 ± 1.08
BCG + Cytokines Mixture (CM)	46.34 ± 4.17^b	13.53 ± 5.58^b
BCG + CM + GLP (50 mg·k^-1)	23.98 ± 6.33^a^d	4.11 ± 2.26^d
BCG + CM + GLP (200 mg·k^-1)	20.61 ± 3.74^d	3.49 ± 1.38^d

^aP < 0.05,

^bP < 0.01 compared with BCG-pretreated group; ^cP < 0.05,

^dP < 0.01 compared with BCG + CM group. n = 7 mice. (3 wells for each treatment in each experiment).

Citation: Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB. Hepatoprotective role of ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. World J Gastroenterol 2002; 8(4): 728-733
URL: https://www.wjgnet.com/1007-9327/full/v8/i4/728.htm
DOI: https://dx.doi.org/10.3748/wjg.v8.i4.728