Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance

Table 1 Clinical profiles of patients with HCC: Comparison with p28 mRNA expression

Variables	n	mRNA levela	Df	p-valueb
Age (years)			62	0.231
< 40	18	2.910 ± 0.695
40-60	35	2.790 ± 0.367
> 60	11	1.673 ± 0.546
Sex			62	0.401
Male	58	2.734 ± 0.422
Female	6	2.650 ± 0.238
HBsAg			62	0.269
Positive	45	2.919 ± 0.426
Negative	19	2.317 ± 0.362
Cirrhosis			62	0.180
Absent	17	3.157 ± 0.885
Present	47	2.631 ± 0.301

Abbreviations: HBsAg, hepatitis B surface antigen.

^aResults were expressed as the mean ± standard deviation.

^bp-value was based on the analysis of variance (ANOVA) or Student's t-test, variances were adjusted by Bartlett's method.

Table 2 Clinicopathological features of patients with HCC: Comparison with p28 mRNA expression

Variables	n	mRNA levela	Df	p-valueb
Serum AFP (ng/mL)			62	0.330
< 25	14	2.439 ± 0.362
25-1000	21	2.469 ± 0.273
> 1000	29	2.821 ± 0.389
Tumor size (cm)			62	0.124
< 5	21	2.393 ± 0.206
5-10	27	2.852 ± 0.468
> 10	16	3.001 ± 0.652
Capsule formation			62	0.242
Positive	46	2.661 ± 0.421
Negative	18	3.016 ± 0.460
Fibrous capsular infiltration			44	0.240
Positive	21	2.833 ± 0.636
Negative	25	2.513 ± 0.226
Hepatic vein involvement			62	0.047
Positive	19	3.726 ± 0.306
Negative	45	2.442 ± 0.532
Satellite nodules			62	0.243
Absent	32	2.467 ± 0.209
Present	32	2.931 ± 0.554
Portal vein thrombus			62	0.021
Absent	46	2.390 ± 0.230
Present	18	3.971 ± 0.384
Histological gradec			62	0.466
I-II	20	2.809 ± 0.538
III-IV	44	2.859 ± 0.655

Abbreviations: serum AFP, serum alpha-fetoprotein.

^aResults were expressed as the mean ± standard deviation.

^bp-value was based on the analysis of variance (ANOVA) or Student's t-test, variances were adjusted by Bartlett'smethod. ^cAccording to Edmonson and Steiner's classification.