Expression of focal adhesion kinase and α5 and β1 integrins in carcinomas and its clinical significance

Table 1 Expression of FAK and integrin subunits α5 and β1 in human gastric carcinomas and their relation to clinical and histological variables

	FAK		Integrin α5		Integrin β1
	-/+	++/+++	-/+	++/+++	-/+	++/+++
Type of tissues
Unaffected margin specimen	49	2	12	39	8	43
Gastric carcinoma	32	43	53	22	56	19
	P < 0.01		P < 0.01		P < 0.01
Differentiation
Poor	14	30	36	8	37	7
Moderate or well	18	13	17	14	19	12
	P < 0.05		P < 0.05		P < 0.01
Extent of invasion
Mucosa or superficial stratum	13	3	11	5	12	4
Deep or full stratum	19	40	42	17	44	15
	P < 0.01		NS		NS
Metastasis
Absent	23	13	26	10	29	7
Present	19	30	27	12	27	12
	P < 0.01		NS		NS

NS: No significant

Table 2 Expression of FAK and integrin subunits α5 and β1 in human colorectal carcinomas and their relation to clinical and histological variables

	FAK		Integrin α5		Integrin β1
	-/+	++/+++	-/+	++/+++	-/+	++/+++
Type of tissues
Unaffected margin specimen	49	2	12	39	8	43
Gastric carcinoma	32	43	53	22	56	19
	P < 0.01		P < 0.01		P < 0.01
Differentiation
Poor	14	30	36	8	37	7
Moderate or well	18	13	17	14	19	12
	P < 0.05		P < 0.05		P < 0.01
Extent of invasion
Mucosa or superficial stratum	13	3	11	5	12	4
Deep or full stratum	19	40	42	17	44	15
	P < 0.01		NS		NS
Metastasis
Absent	23	13	26	10	29	7
Present	19	30	27	12	27	12
	P < 0.01		NS		NS

NS: No significant

Table 3 Expression of FAK and integrin subunits α5 and β1 in human hepatocellular carcinomas and their relation to clinical and histological variables

	FAK		Integrin α5		Integrin β1
	-/+	++/+++	-/+	++/+++	-/+	++/+++
Type of tissues
Unaffected margin specimen	15	1	3	13	1	15
Hepatocellular carcinoma	4	12	11	5	10	6
	P < 0.01		P < 0.01		P < 0.01
Differentiation
Poor	1	7	8	0	7	1
Moderate or well	2	5	3	4	4	5
	P < 0.05		P < 0.05		P < 0.01

Table 4 Expression of FAK and integrin subunits α5 and β1 in human uterocervical carcinomas and their relation to clinical and histological variables

	FAK		Integrin α5		Integrin β1
	-/+	++/+++	-/+	++/+++	-/+	++/+++
Type of tissues
Unaffected margin specimen	18	0	13	5	9	9
adenocarcinoma	9	1	9	9	1	9
Squamous carcinoma	10	0	10	0	9	1
	P < 0.05		P < 0.05		P < 0.05
Differentiation
Poor	9	1	10	0	9	1
Moderate or well	10	0	9	1	9	1
	P < 0.05		P < 0.05		P < 0.05
Extent of invasion
Mucosa or superficial stratum	5	0	8	0	4	1
Deep or full stratum	14	1	14	1	14	1
	P < 0.05		NS		NS

NS: No significant