Effect of jianpiyiwei capsule on gastric precancerous lesions in rats

Table 1 Effects of JPYW on macroscopical changes of gastric precancerous lesions in rats

group	n	erosion/ulceration	Disarrayed plicae	thinning of mucosa	white nodules	xanthochromia of mucosa
normal	10	0	0	1	0	0
model	11	6b	7b	9b	9b	5a
negative	10	6a	6a	9b	10b	5a
1.5 g/kg•d⁻¹	10	2	1ce	3cf	3cf	1ce
4.5 g/kg•d⁻¹	10	0de	0de	1df	2df	0

n: number; normal: normal group; model: model group; negative: negative control group; 1.5 g/kg·d^-1: JPYW 1.5 g/kg·d^-1 group; 4.5 g/kg·d^-1:JPYW 4.5 g/kg·d^-1 group

^aP < 0.05,

^bP < 0.01, vs normal group;

^cP < 0.05,

^dP < 0.01, vs model group;

^eP < 0.05,

^fP < 0.01, vs negative control group.

Table 2 Effects of JPYW on histological changes of gastric precancerous lesions in rats

group	n	CSG	CAG	dysplasia	IM
normal	10	1	0	0	0
model	11	11b	10b	8b	3
negative	10	10b	10b	8b	5b
1.5 g/kg•d⁻¹	10	3df	5df	2ce	1
4.5 g/kg•d⁻¹	10	2df	1df	1df	0e

n: number; normal: normal group; model: model group; negative: negative control group; 1.5 g/kg·d^-1: JPYW 1.5 g/kg·d^-1 group; 4.5 g/kg·d^-1:JPYW 4.5 g/kg·d^-1 group ^aP < 0.05,

^bP < 0.01, vs normal group;

^cP < 0.05,

^dP < 0.01, vs model group;

^eP < 0.05,

^fP < 0.01, vs negative control group.

Table 3 Automatic imaging pattern analysis effects of JPYW (¯x ± s, n = 10)

group	T1/T2 in gastric body	T1/T2 in antrum	N/C	P1/D1	P2/D2
normal	10.6 ± 0.0	5.9 ± 0.0	0.54 ± 0.02	3.53 ± 0.08	3.43 ± 007
model	1.9 ± 0.4b	1.3 ± 0.2b	0.75 ± 0.04b	4.18 ± 009b	3.69 ± 0.08b
negative	1.8 ± 0.5b	1.1 ± 0.1bc	0.78 ± 0.02bc	4.39 ± 010bd	3.95 ± 008bd
1.5 g/kg·d-1	4.3 ± 0.6bdf	3.1 ± 0.7bdf	0.62 ± 002bdf	3.62 ± 0.09adf	3.55 ± 006bdf
4.5 g/kg·d-1	8.9 ± 1.8df	5.3 ± 09df	0.55 ± 0.03df	3.57 ± 0.07df	3.46 ± 007df

normal: normal group; model: model group; negative: negative control group; 1.5 g/kg·d^-1: JPYW 1.5 g/kg·d^-1 group; 4.5 g/kg·d^-1: JPYW 4.5 g/kg·d^-1 group

^aP < 0.05,

^bP < 0.01, vs normal group;

^cP < 0.05,

^dP < 0.01, vs model group; ^eP < 0.05,

^fP < 0.01, vs negative control group.

Table 4 Effects of JPYW on GMBF and the gastric mucosal hexosamines and MDA contents (¯x ± s)

group	n	GMBF (mV)	Hexosamines (mg/g)	MDA (μmol/g)
normal	10	0.29 ± 0.05	6.8 ± 1.12	46 ± 25
model	11	0.17 ± 0.04b	4.8 ± 0.7b	374 ± 49b
negative	10	0.18 ± 0.04b	4.9 ± 0.8b	419 ± 43bc
1.5 g/kg·d-1	10	0.27 ± 0.07de	5.2 ± 1.2b	312 ± 56bce
4.5 g/kg·d-1	10	0.29 ± 0.05de	5.6 ± 0.9ac	271 ± 40bce

n: number; normal: normal group; model: model group; negative: negative control group; 1.5 g/kg·d^-1: JPYW 1.5 g/kg·d^-1 group; 4.5 g/kg·d^-1:JPYW 4.5 g/kg·d^-1 group

^aP < 0.05,

^bP < 0.01, vs normal group;

^cP < 0.05,

^dP < 0.01, vs model group;

^eP < 0.05, ^fP < 0.01, vs negative control group.