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©The Author(s) 2002.
World J Gastroenterol. Jun 15, 2002; 8(3): 515-519
Published online Jun 15, 2002. doi: 10.3748/wjg.v8.i3.515
Published online Jun 15, 2002. doi: 10.3748/wjg.v8.i3.515
Table 1 The effect of IH764-3 on 3H-TdR incorporation (-x±s)
Table 2 Apoptotic rates of HSCs exposed IH764-3 with different doses by Annexin-V/PI (%)
Time doses | 0 μg·mL-1 | 10 μg·mL-1 | 20 μg·mL-1 | 30 μg·mL-1 | 40 μg·mL-1 |
12 hr | 0.3 | 2.2 | 3.7 | 6.7 | 15.1 |
48 hr | 2.3 | 6.7 | 9.3 | 15.1 | 19.7 |
Table 3 Percentage of apoptotic HSCs exposed to IH764-3 (30 μg·mL-1) at different time points by Annexin-V/PI (%)
Time | 0 hr | 12 hr | 24 hr | 48 hr | 72 hr |
Apoptosis rate | 0.3 | 6.7 | 10.3 | 15.1 | 19.6 |
Table 4 Fluorescence index of caspase-3 protein in HSCs (-x±s)
Dosage (μg·mL-1) | Caspase-3 | P value |
0 | 175.6 ± 22.5 | |
10 | 215.1 ± 26.9 | < 0.01 |
20 | 231.6 ± 28.6 | < 0.01 |
30 | 304.7 ± 30.7 | < 0.01 |
40 | 338.9 ± 32.1 | < 0.01 |
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Citation: Zhang XL, Liu L, Jiang HQ. Salvia miltiorrhiza monomer IH764-3 induces hepatic stellate cell apoptosis
via caspase-3 activation. World J Gastroenterol 2002; 8(3): 515-519 - URL: https://www.wjgnet.com/1007-9327/full/v8/i3/515.htm
- DOI: https://dx.doi.org/10.3748/wjg.v8.i3.515