Clinicopathological study on TTV infection in hepatitis of unknown etiology

Table 1 TTV DNA in liver tissues of hepatitis

Type	n	TTV (+) n (%)	TTV (-) n (%)	TTV alone n (%)
AH	51	14 (27.5)	37 (72.5)	5 (9.8)
CH	41	15 (36.6)	26 (63.4)	6 (14.6)
ASH	9	0 (0.0)	9 (100.0)	2 (18.2)
SSH	11	5 (45.5)	6 (54.5)	0 (0.0)
CSH	5	2 (40.0)	3 (60.0)	0 (0.0)
LC	11	4 (36.4)	7 (63.6)	0 (0.0)
HCC	8	4 (50.0)	4 (50.0)	0 (0.0)
Total	136	44 (32.4)	92 (67.6)	13 (9.6)
Normal	31	8 (25.8)	23 (74.2)

Table 2 TTV DNA in sera of patients

Type	n	TTV (+) n (%)	TTV (-) n (%)
NA-NG	61	21 (34.4)	40 (65.6)
A-G	126	27 (21.4)	99 (78.6)
AH	62	18 (29.0)	44 (71.0)
CH	81	19 (23.5)	62 (76.5)
SH	17	9 (52.9)	8 (47.1)a
LC	27	2 (7.4)	25 (92.6)
Total	187	48 (25.7)	139 (74.3)
Control	20	3 (15.0)	17 (85.0)

^aP < 0.05, vs Control

Table 3 TTV DNA genome and its complement chain in liver and extrahepatic tissues by PCR using single-strand probes

No.	Diagn.	Liver			Pancreas			Kidney			Spleen			Heart
		DP	P37	P38	DP	P37	P38	DP	P37	P38	DP	P37	P38	DP	P37	P38
1	CSH	+	+	+	-	+	-	+	+	-	+	+	-	-	／	／
2	CSH	+	-	+	-	-	-	+	-	-	+	-	-	／	／	／
3	HCC	+	+	-	+	+	-	-	-	-	+	+	-	／	／	／
4	HCC	+	+	-	-	+	-	-	-	-	-	-	-	／	／	／
5	LC	+	+	+	+	+	-	+	+	-	+	+	-	+	／	／
6	LC	+	+	+	+	+	-	-	-	-	+	+	-	／	／	／
7	LC	+	+	+	+	+	-	+	+	-	-	+	-	／	／	／
8	SSH	+	+	-	+	+	-	+	-	-	-	-	-	／	／	／

DP: double-strand probe

Table 4 Liver function of cases infected by TTV alone and by HBV alone

	Pathogen	ALT (nkat•L⁻¹)	TSB (μmol•L⁻¹)
AH	TTV alone	325 ± 222b	91 ± 115
	HBV alone	931 ± 630	134 ± 118
SH	TTV alone	509 ± 361	304 ± 125
	HBV alone	435 ± 239	226 ± 96
CH	TTV alone	187 ± 150	98 ± 199

^bP < 0.01, vs HBV