Preventive effect of glutamine on intestinal barrier dysfunction induced by severe trauma

Table 1 Changes in plasma DAO in trauma animal model (^-x±s× 10³ U·L^-1)

Animal model	Before injury	T (after injury)/h
		2	6	24	48	72
Goat	0.9 ± 0.8	1.9 ± 1.1a		1.2 ± 0.2	3.0 ± 2.6	4.7 ± 1.2b
Rats	1.3 ± 0.4	2.2 ± 0.7b	2.3 ± 0.87b	1.2 ± 0.6	1.1 ± 0.5
Scalded rats	0.8 ± 0.9	0.8 ± 1.8b		1.1 ± 0.6	2.4 ± 2.1a
Burnd pigs	4.1 ± 1.4	4.7 ± 1.5		4.7 ± 1.4	4.8 ± 1.1	5.8 ± 1.4a
Gun shooting	1.5 ± 0.6	1.2 ± 0.5	2.0 ± 0.6b	1.9 ± 0.2b

Dog in hypothermia

^aP < 0.05;

^bP < 0.01, vs before injury.

Table 2 Changes in parameters in goats after hemorrhagic shock com-bined with endotoxin infusion

	Before injury	T (after injury)/h
		2	24	48	72
TNF/ μg·L-1	0.08 ± 0.02	0.03 ± 0.25a	0.17 ± 0.09a	0.34 ± 0.15a	0.33 ± 0.18a
LPS/ × 103Eu·L-1	0.14 ± 0.03	0.16 ± 0.04	0.21 ± 0.02a	0.18 ± 0.16	0.37 ± 0.10b
Laclate/nmol·L-1	9.03 ± 2.19	18.30 ± 2.56a	9.81 ± 2.83	12.01 ± 6.84	43.61 ± 11.27b
L/M rat	0.03 ± 0.01	0.41 ± 0.27	0.62 ± 0.20		1.70 ± 0.60b
Intestinal pHi	7.03 ± 0.05	7.05 ± 0.06b	7.14 ± 0.09b	7.20 ± 0.08a	7.05 ± 0.07b

^aP < 0.05;

^bP < 0.01, vs before injury.

Table 3 Correlation analysis in goats subjected to hemorrhagic shock combined with endotoxin infusion

X	Y	r	P
DAO	TNFα	0.817	< 0.01
DAO	LPS	0.842	< 0.01
DAO	Laclate	0.872	< 0.01
DAO	l/m	0.951	< 0.01
DAO	Intestinal pHi	-0.553	< 0.05