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©The Author(s) 2001.
World J Gastroenterol. Dec 15, 2001; 7(6): 792-795
Published online Dec 15, 2001. doi: 10.3748/wjg.v7.i6.792
Published online Dec 15, 2001. doi: 10.3748/wjg.v7.i6.792
Table 1 Distribution of selected variables in gastric cancer group and group
| Gastric cancer (n = 91) | Control (n = 94) | P value | |
| n (%) | n (%) | ||
| Age/y | |||
| < 50 | 21 (23.1) | 22 (23.4) | |
| 50-59 | 22 (24.2) | 22 (23.4) | |
| 60-69 | 32 (35.2) | 34 (36.2) | |
| 70+ | 16 (17.6) | 16 (17.0) | 0.9983 |
| mean ± SD | 58.4 ± 10.9 | 58.2 ± 11.0 | |
| Range | 32-78 | 34-79 | |
| Gender | |||
| Male | 77 (84.62) | 82 (87.23) | |
| Female | 14 (15.38) | 12 (12.77) | 0.6094 |
| Education | |||
| College | 1 (1.1) | 1 (1.1) | |
| High school | 15 (16.5) | 63 (67.0) | |
| Elementary school | 57 (62.6) | 22 (23.4) | |
| Illiterate | 18 (19.8) | 8 (8.5) | 0.0000 |
| Smoking/y | |||
| 0 | 31 (34.1) | 60 (63.8) | |
| < 10 | 2 (2.2) | 16 (17.0) | |
| 10- | 16 (17.6) | 7 (7.5) | |
| 20- | 22 (24.2) | 4 (4.3) | |
| 30- | 20 (22.0) | 7 (7.5) | 0.0000 |
| Alcohol drinking/y | |||
| 0 | 40 (44.0) | 66 (70.2) | |
| < 10 | 3 (3.3) | 13 (13.8) | |
| 10- | 14 (15.4) | 8 (8.5) | |
| 20- | 34 (37.4) | 7 (7.5) | 0.0000 |
| Fish sauce intake | |||
| Low (< 3 times/w) | 17 (18.68) | 69 (73.40) | |
| High (≥ 3 times/w) | 76 (81.32) | 25 (26.60) | 0.0000 |
Table 2 Cytochrome P450 2E1 genotype and risks of gastric cancer
| CYP2E1 | Gastric cancer | Control (n = 94) | OR (95%CI) | ||
| n | (%) | n | (%) | ||
| C1/C1 | 58 | (63.7) | 71 | (75.5) | 1.00 |
| C1/C2 | 27 | (29.7) | 22 | (23.4) | 1.50 (0.74-3.07) |
| C2/C2 | 6 | (6.6) | 1 | (1.1) | 7.34 (0. 84-166.60) |
Table 3 The allele frequencies of CYP2E1 in gastric cancer group and control group
| C1 | C2 | |||
| n | Frequencies | n | Frequencies | |
| Gastric cancer | 143 | 0.7857 | 39 | 0.21 43 |
| Controls | 164 | 0.8723 | 24 | 0.1276 |
Table 4 Relationships between CYP2E1 together with selected variables and risk of gastric cancer
| CYP2E1 | Variables Smoking | Gastric cancer | Controls | OR (95%CI) |
| C1/C1 | No | 21 | 48 | 1.00 |
| C1/C1 | Yes | 37 | 23 | 3.68 (1.67-8.19) |
| C1/C2 or C2/C2 | No | 10 | 12 | 1.90 (0.64-5.69) |
| C1/C2 or C2/C2 | Yes | 23 | 1 1 | 4.78 (1.82-12.78) |
| Alcohol drinking | ||||
| C1/C1 | No | 26 | 51 | 1.00 |
| C1/C1 | Yes | 32 | 20 | 3.14 (1.42-6.99) |
| C1/C2 or C2/C2 | No | 14 | 15 | 1.83 (0.70- 4.77) |
| C1/C2 or C2/C2 | Yes | 19 | 8 | 4.66 (1.65-13.53) |
| Fish sauce intakea | ||||
| C1/C1 | Low | 11 | 53 | 1.00 |
| C1/C1 | High | 47 | 18 | 12.58 (5.40-29.34) |
| C1/C2 or C2/C2 | Low | 6 | 16 | 1.81 (0.58-5.66) |
| C1/C2 or C2/C2 | High | 27 | 7 | 18.58 (6.47-53.37) |
- Citation: Cai L, Yu SZ, Zhang ZF. Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle, Fujian Province. World J Gastroenterol 2001; 7(6): 792-795
- URL: https://www.wjgnet.com/1007-9327/full/v7/i6/792.htm
- DOI: https://dx.doi.org/10.3748/wjg.v7.i6.792