Effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells

Table 1 Increased values of MMP-2, TIMP-2 proteins and activity of MMP-2 in supernatants in three hypoxia periods

t/h	MMP-2		TIMP-2		MMP-2 activity
	n	¯x ± s	n	¯x ± s	n	¯x ± s
6	12	0.0264 ± 0.0168b	12	-0.0042 ± 0.0100	9	-1.110 ± 2.612
12	12	0.0026 ± 0.0111	12	0.0023 ± 0.0181	11	-0.392 ± 1.543
24	10	0.0100 ± 0.0136a	10	-0.0012 ± 0.0140	10	-1.323 ± 2.194

^aP ＜ 0.05 vs 6 h;

^bP ＜ 0.01 vs 12 h.

Table 2 Changes of MMP-2, TIMP-2 contents and activity in supernatant in hyperoxia group

Group	MMP-2		TIMP-2		MMP-2 activity
	n	¯x ± s	n	¯x ± s	n	¯x ± s
Hyperoxia	16	0.1958 ± 0.0448	16	0.0499 ± 0.0144b	14	5.252 ± 0.771a
Control	15	0.1729 ± 0.0409	14	0.0219 ± 0.0098	12	4.304 ± 1.083

^aP ＜ 0.05,

^bP ＜ 0.01 vs control.