Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: A case-control study

Table 1 Main characteristics of cases and controls

	Cases (n = 95)		Controls (n = 94)
	n	(%)	n	(%)
Age groups/yr
< 50	21	(22.1)	22	(23.4)
50-59	23	(24.2)	22	(23.4)
60-69	33	(34.7)	34	(36.2)
≥ 70	18	(19.0)	16	(17.0)
Mean age	59 ± 11		58 ± 11
Age range	32-78		34-79
Gender
Male	81	(85.3)	82	(87.2)
Female	14	(14.7)	12	(12.8)
Education
College	1	(1.1)	1	(1.1)
High school	15	(15.8)	63	(67.0)
Elementary	61	(64.2)	22	(23.4)
school
Illiterate	18	(19.0)	8	( 8.5)

Table 2 Association between GSTM1 and gastric cancer risk

	GSTM1 genotype
	Nonnull	n	(%)	null	n	(%)
Contr		51	54.3		43	45.7
Case		35	36.8		60	63.2
Crude OR (95%CI)				2.03 (1.13-3.65)
Adjusted ORa (95%CI)				2.03 (1.13-3.68)
Adjusted ORb (95%CI)				2.47 (1.21-5.03)
Adjusted ORc (95%CI)				2.63 (1.17-5.88)

a: Logistic regression adjusted for age and sex; b: Adjusted for age, sex, cigarette smoking and alcohol drinking (yes/no); c: Adjusted for age, sex, cigarette smoking, alcohol drinking (yes/no), and fish sauce intake (continuous).

Table 3 Association between gastric cancer and combinations of GSTM1 and GSTT1 genotypes

GSTM1	GSTT1	Case		Contr		OR (95%CI)
		n	%	n	%
Non-null	Non-null	21	22.1	30	31.9	1.00
Non-null	Null	14	14.7	21	22.3	0.95 (0.36-2.50)
Null	Null	27	28.4	26	27.7	1.48 (0.64-3.47)
Null	Non-null	33	34.7	17	18.1	2.77 (1.15-6.77)

Table 4 Risk of gastric cancer in relation to GSTM1 genotypes by e smoking

Genotype	Smoke	Contr		Case		OR (95%CI)
		n	%	n	%
Nonnull	No	28	29.8	12	12.6	1.00
Null	No	32	34.0	22	23.2	1.60 (0.62-4.19)
Nonnull	Yes	23	24.5	23	24.2	2.33 (0.88-6.28)
Null	Yes	11	11.7	38	40.0	8.06 (2.83-23.9)