Influence of IFN&alpha;-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma

doi:10.3748/wjg.v7.i3.419

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Jun 15, 2001 (publication date) through Oct 30, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 2001; 7(3): 419-421
Published online Jun 15, 2001. doi: 10.3748/wjg.v7.i3.419

Table 1 The influence of biological immunal modulants on the release of TNF and IL-1 by KCs of normal rat in vivo

Groups	TNF (ng/L)	IL-1 (SI)
Control	56.2 ± 10.5	1.40
BCG	79.4 ± 17.6^a	2.27^b
IFNα-2b	134.9 ± 51.4^b	1.84^a
IFNα-2b + BCG	199.5 ± 71.5^b	2.54^b

n = 18,

^aP < 0.05,

^bP < 0.01 vs control.

Full Size Table

Table 2 The influence of biological immunal modulants on the release of TNF and IL-1 by KCs of rats with hepatoma in vivo

Groups	2^nd week		16^th week
Groups	TNF (ng/L)	IL-1 (SI)	TNF (ng/L)	IL-1 (SI)
Control	50.1 ± 9.4	1.57	79.4 ± 10.6	1.58
BCG	234.4 ± 63.1^b	2.58^b	148.5 ± 47.2^a	2.74^b
IFNα-2b	251.2 ± 82.1^b	2.33^b	166.0 ± 30.5^a	2.42^b
IFN-2b + BCG	281.8 ± 63.3^b	2.80^b	354.8 ± 96.4^b	4.08^b

n = 18,

^aP < 0.05,

^bP < 0.01 vs control.

Full Size Table

Table 3 The influence of biological immune modulants on the release of TNF and IL-1 by KCs of rats with hepatoma in vitro

Groups	TNF (ng/L)	IL-1 (SI)
Control	100.0 ± 20.6	1.42
BCG	141.3 ± 31.7^b	1.80^a
IFNα-2b	199.5 ± 61.2^b	1.64^a
IFNα-2b + BCG	223.8 ± 42.4^b	2.24^b

n = 18,

^aP < 0.05,

^bP < 0.01 vs control.

Full Size Table

Citation: Bai XY, Jia XH, Cheng LZ, Gu YD. Influence of IFNα-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma. World J Gastroenterol 2001; 7(3): 419-421
URL: https://www.wjgnet.com/1007-9327/full/v7/i3/419.htm
DOI: https://dx.doi.org/10.3748/wjg.v7.i3.419