Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma

Table 1 Patient characteristics: risk factors for HCC

Variable	Number/Total	Percentage
Sex
Male	72/95	76%
Female	23/95	24%
Markers of past or present HBV infection
Yes	25/85	29%
No	60/85	71%
Markers of HCV infection
Yes	21/85	25%
No	64/85	75%
Markers of both HBV and HCV-infection
Yes	6/85	7%
No	79/85	93%
History of alcoholism
Yes	31/90	34%
No	59/90	66%
Cirrhosis
Yes	79/94	84%
No	15/94	16%
Child score (only cirrhotics)
A	29/79	37%
B	32/79	40%
C	18/79	23%
AFP elevated
Yes	61/91	67%
No	30/91	33%

Table 2 Patient characteristics: age and clinical chemistry results

Variable	Median (Range)
Age	64 (31-85) years
GPT	32 (10-244) U/L
AP	214 (2-1490) U/L
Bilirubin	1.5 (0.4-14.4) mg/dL
Prothrombin time acc. to Quick	83 (25-122)%
Albumen	3.4 (1.9-4.6) g/dL
AFP	38 (0.9-831000) μg/L

Table 3 Tumor characteristics during initial presentation

Variable	Number/Total	Percentage
Type of tumor growth
One nodule	38/94	40%
> 1 Nodule	31/94	34%
Diffuse	25/94	26%
Size of largest nodule
< 3 cm	20/89	22%
3 cm-5 cm	31/89	35%
> 5 cm	38/89	43%
Involvement of both liver lobes
Yes	49/93	53%
No	44/93	47%
Portal vein thrombosis
Yes	19/94	20%
No	75/94	80%
Lymph node metastases
Yes	10/92	11%
No	82/92	89%
Distant metastases
Yes	8/93	9%
No	85/93	91%
Presence of ascites
Yes	43/95	45%
No	52/95	55%
Tumor stage according to Okuda
I	28/94	30%
II	53/94	56%
III	13/94	14%

Table 4 Comparison of viral parameters with studies reported in the literature

Author	Number	Cirrhosis	HBV	HCV	HBV + HCV (%)	Country
Northern/Central Europe
Van Roey	154	60	52	55	NA	Belgium
Widell	95	NA	29	17	NA	Sweden
Kubicka	268	74.6	35.1	26.9	10	Germany
Petry	100	89.5	22	37	0	Germany
Peters	86	90	49	37	NA	Germany
This study	95	84	29	25	7	Germany
Southern Europe
Kuper	333	NA	58	12	3	Greece
Stroffolini	1148	NA	12	71	5	Italy
Asia
Kubo	330	NA	17	26	53	Japan
Shiratori	205	NA	11	71	13	Japan
Zhang	113	NA	63	11	NA	China
Chuang	128	NA	77	20	NA	China