Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance

Table 1 Expressions of p42/44^MAPK, p-Stat3, c-fos and c-jun proteins in HCCs, PCLTs and normal liver tissues

Groups	No	p42/44MAPK				p-Stat3				c-fos				c-jun
		-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++
Normal	9	9	0	0	0	8	1	0	0	9	0	0	0	9	0	0	0
PCLT	55	37	9	7	2	42	4	7	2	36	12	7	0	39	13	3	0
HCC
Grade I	10	1	4	4	1	5	1	2	2	8	1	1	0	4	4	1	1
Grade II	21	3	6	12	0	2	12	5	2	3	12	4	2	1	15	4	1
Grade III	17	1	9	2	5	4	3	6	4	2	4	8	3	2	8	5	2
Grade IV	7	2	1	3	1	3	1	3	0	0	1	2	4	0	0	2	5

Table 2 Relationship in expressive strengthes of p42/44^MAPK, c-fos and c-jun proteins between HCCs and PCLTs

Groups	r	P
HCC
p42/44MAPK/c-fos	0.44835	< 0.01
p42/44MAPK/c-jun	0.3054	< 0.01
PCLT
p-MAPK/c-fos	0.9433	< 0.01
p-MAPK/c-jun	0.1472	> 0.05

Table 3 Relationship in expression strength of p-Stat3, c-fos and c-jun proteins between HCCs and PCLTs

Groups	r	P
HCC
p-Stat3/c-fos	0.3967	< 0.01
p-Stat3/c-jun	0.5444	< 0.01
PCLT
p-Stat3/c-fos	0.0499	> 0.05
p-MAPK/c-jun	0.3596	< 0.01