Effect of arsenic trioxide on human hepatoma cell line BEL-7402 cultured in vitro

Table 1 Influence of varying concentrations of arsenic trioxide on apoptotic rate and DNA distribution

Group	Apoptotic rate	DNA distribution (%)
		G0/G1	S
Control	9.31 ± 0.24	62.91 ± 1.30	33.77 ± 0.41
0.5 μmol/L As2O3	15.53 ± 0.69	60.92 ± 2.16	36.87 ± 2.46
1 μmol/L As2O3	19.10 ± 1.02a	57.55 ± 2.24	40.14 ± 2.87
2 μmol/L As2O3	21.87 ± 0.84a	54.12 ± 1.18	43.17 ± 2.30

Treated group vs control group,

^aP < 0.05.

Table 2 Influence of arsenic trioxide on expression of Bcl-2 and Bax (%)

	Control	As2O3 concentration (μmol/L)
		0.5	1	2
Bcl-2 expression	4.33 ± 0.29	8.81 ± 0.84	46.00 ± 3.61b	83.08 ± 8.16b
Bax expression	15.33 ± 1.04	3.83 ± 0.29b	87.33 ± 2.02b	95.83 ± 2.36b

Treated group vs control group,

^bP < 0.01.