Deng DJ. Progress of gastric cancer etiology: N-nitrosamides 1999s. World J Gastroenterol 2000; 6(4): 613-618 [PMID: 11819660 DOI: 10.3748/wjg.v6.i4.613]
Corresponding Author of This Article
Dr. Da-Jun Deng, Laboratory of Cancer Etiology, Beijing Medical University School of Oncology & Beijing Institute for Cancer Research, Western Destrict, Beijing 100034, China. dengdajun@sina.com
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Editorials
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World J Gastroenterol. Aug 15, 2000; 6(4): 613-618 Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.613
Table 1 Comparison of formation of NMU at various doses of NaNO2 in gastric lumen of pig model in vivo and control experiments in vitro[9,22]
Formation of NMU
Amount of NaNO2(μmol)
Concentration (μmol/L)
Total amount (μmole)
in vivo
in vivo
in vivo
in vivo
3480
25.40
29.20
4.27
1.75
870
7.97
6.48
1.91
0.38
220
ND
2.77
ND
0.17
Table 2 Status of gastric juice samples from four human volunteers and formation of NMU 30 min after taking 40 mL of diluted fish sauce and 500 μmol of nitrite[9]
Sample’s origin
Total volume of sample (mL)
pH of sample
Total amount of NMU detected in gastric lumen (nmol)
Male A
24
5.0
4
Male B
110
3.0
85
Female A
50
2.0
100
Female B
50
2.0
22
Table 3 Relationship between presence of total N-nitrosamides in gastric juice samples from subjects with pathological changes in gastric mucosa
Gastric mucosal status
Positive rate of total N-nitrosamides in gastric juice samples (%)**