Copyright
©The Author(s) 2000.
World J Gastroenterol. Aug 15, 2000; 6(4): 475-482
Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.475
Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.475
Gene | Locus | mRNA size | Tandem Repeats | Other structural features | Expression in normal tissues |
MUC1 | 1q21-24 | 4-7 kb | 20 AA | Transmembrane | Most epithelia |
MUC2 | 11p15.5 | 14-16 kb | 23 AA, -16 AA | D-domains, cystine knot | Colon > small intestine > respiratory tract |
MUC3 | 7q22 | 16-17.5 kb | 17 AA, 59 AA | Cystine knot | Small intestine > colon, gall bladder |
MUC4 | 3q29 | 16.5-24 kb | 16 AA | Respiratory tract, cervix > GI tract | |
MUC5AC | 11p15.5 | 17-18 kb | 8 AA | D-domains, cystine knot | Stomach (surface) > respiratory tract |
MUC5B | 11p15.5 | 17.5 kb | 29 AA, interrupted | D-domains, cystine knot | Respiratory tract, salivary gland, cervix > GI tract |
MUC6 | 11p15.5 | 16.5-18 kb | 169 AA | Cystine knot | Stomach (glands), gall bladder |
MUC7 | 4 | 2.4 kb | 23 AA | No homology to large mucins | Salivary glands |
MUC8 | 12q24.3 | -9 kb | 18 AA, 41 AA | Not Thr/Ser rich | Trachea |
Antigen | H.pylori negative | H.pylori positive | |
MUC5AC | % Stained*a, intensity score (surface) | (69.8% ± 3.5%), 2.8 ± 0.1 | (51.2% ± 5.7%), 2.6 ± 0.1 |
MUC6 | % Stained**a, intensity score (surface)a | 4%, 0.1 ± 0.1 | 72%, 1.8 ± 0.2 |
Le\ + b | % Stained**a, intensity score (surface)a | 63%, 0.9 ± 0.2 | 96%, 1.9 ± 0.2 |
Paradoxical ConA | % Stained**a, intensity score (surface)a | 18%, 0.4 ± 0.2 | 79%, 2.1 ± 0.3 |
LeX | % Stained**a, intensity score (surface)a | 4%, 0.4 ± 0.4 | 59%, 1.0 ± 0.2 |
MUC1 | Intensity score (surface), intensity score(glands) | 2.6 ± 0.2, 1.7 ± 0.1 | 2.7 ± 0.1, 1.4 ± 0.2 |
Sialyl Tn | Intensity score (surface), intensity score (glands)a | 1.8 ± 0.2, 1.9 ± 0.1 | 1.6 ± 0.1, 1.4 ± 0.1 |
- Citation: Byrd JC, Bresalier RS. Alterations in gastric mucin synthesis by Helicobacter pylori. World J Gastroenterol 2000; 6(4): 475-482
- URL: https://www.wjgnet.com/1007-9327/full/v6/i4/475.htm
- DOI: https://dx.doi.org/10.3748/wjg.v6.i4.475