Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa

Table 1 Correlation between methylation of p16 gene and age, enzyme cutting site of normal clonic mucosa

	Number of site	Full methylation	Partial methylation	Un-methylation
Age (yrs)
≤ 40	33	4	3	26a
41-60	60	19	8	33
> 60	87	23	8	56
Site
Hpa-II	60	13	7	40b
Sac-II	60	28	8	24
Sma-I	60	5	4	51

^a0.1 > P > 0.05,

^bP < 0.005.

Table 2 Correlation between methylation of p16 gene and clinicopathologic parameters of colorectal carcinoma

	Numbers of site	Full methylation	Partial methylation	Un-methylation
Histological type
(adenocacinoma)
Well-differentiated	18	6	3	9a
Moderately-differentiated 117	26	14	77
Poorly-differentiated	15	3	2	10
Mucinous	21	6	0	15
Size (cm)
≤ 2.5	27	5	4	18a
2.6-4	54	15	5	34
>4	87	21	10	56
Lymph node metastases
With LN metastases	78	20	5	53a
Without LN metastases	102	26	14	62

^aP > 0.05.