Cyclosporin A protects Balb/c mice from liver damage induced by superan tigen SEB and D-GalN

Table 1 Serum ALT activities of Balb/c mice in different time (IU/L, 1IU/L = 16.67 nmol·s^-1/L)

t/h	NS	CSA	SEB	D-GalN	SEB + D-GalN	CSA + SEB + D-GalN
2	51.8 ± 16.4	51.5 ± 17.8	59.5 ± 18.8	71.3 ± 25.7a	69.0 ± 24.6a	54.2 ± 24.5
6	56.0 ± 21.3	63.0 ± 18.1	60.5 ± 20.3	81.3 ± 24.7a	95.7 ± 38.7b	60.7 ± 29.4
12	54.8 ± 14.9	55.5 ± 27.5	56.5 ± 16.9	63.8 ± 22.8	4109.2 ± 1910.1b	60.5 ± 26.7
24	59.7 ± 24.5	59.0 ± 24.7	59.5 ± 24.7	60.7 ± 26.3		65.7 ± 24.2

^aP < 0.05,

^bP < 0.01 vs normal saline.

Table 2 Lethality within 24 h

D-GalN (mg/mice)	SEB (μg/mice)	CSA (mg/mice)	24 h lethality (death/total)
	10		0/3
	50		0/6
	100		0/3
	150		0/3
16			0/6
16	10		0/3
16	50		3/6
16	100		2/3
16	150		3/3
16	50	0.5	0/6
		0.5	0/6
			0/6a

^aMice treated with normal saline.