Relationship between expression of α-fetoprotein messenger RNA and some clinical parameters of human hepatocellular carcinoma

Table 1 The correlation of AFP mRNA in hepatoma tissues and some clinical parameters

Histological parameter	Cases	Positive tumor AFP mRNA	Positive paratumor AFP mRNA
Cirrhosisa
Yes	36	88.8 (32/36)	69.4 (25/36)
No	16	50.0 (8/16)	0.0 (0/16)
HBsAgb
(+)	46	82.6 (38/46)	52.2 (24/46)
(-)	6	33.3 (2/6)	16.7 (1/6)
Differentiation
Well	18	77.8 (14/18)	33.3(6/18)
Poor	34	76.5 (26/34)	55.9 (19/34)
Tumor size
≤ 5 cm	20	75.0 (15/20)	25.0 (5/20)
> 5 cm	32	78.1 (25/32)	62.5(20/32)
Metastasis
Yes	11	81.8(9/11)	45.5(5/11)
No	41	75.6 (31/41)	48.5(20/41)
Capsule
Yes	20	85.0 (17/20)	40.0 (8/20)
No	32	71.9 (23/32)	53.1 (17/32)

^aP < 0.01,

^bP < 0.05.

Table 2 The expression levels of AFP gene in HCC

Group	No. of cases	AFP gene expression -x±sx(%)	P
Total
HCC	52	58.4 ± 6.4
Paratumor	52	30.2 ± 6.1	< 0.01
Cirrhosis
Yes	36	65.5 ± 5.4
No	16	48.2 ± 4.3	< 0.01
Metastasis
Yes	11	57.1 ± 6.4
No	41	55.2 ± 7.8	> 0.05
Capsule
Complete	20	53.1 ± 8.2
Incomplete	32	51.8 ± 6.5	> 0.05
Tumor
≤ 5 cm	20	48.5 ± 5.3
>5 cm	32	53.6 ± 8.3	S > 0.05