A comparison between previous and present histologic assessments of chronic hepatitis C viral infections in humans

Table 1 The frequency of histologic features of chronic HCV viral infection in 79 adults classified by the new and the old classification *

Old classification	New classification
	Normal	Mild	Moderate	Total
Normal(minimal)	7	0	0	7
CPH	34	4	0	38
CAH	0	27	2	29
Cirrhosis	0	4	1	5
Total	41	35	3	79

*Number of patients, Chi-square = 66.9, P < 0.001.

Table 2 Correlation of traditional histologic diagnosis with aminotr ansferases, activity grade, and fibrosis stage in 79 patients with chronic HCV viral infection*

Old classification	ALT	AST	Activity score	Fibrosis score
Normal	57.6 ± 31.4	39.0 ± 0.0	1.0 ± 0.0	0.0 ± 0.0
CPH	94.0 ± 67.5	59.7 ± 31.8	2.0 ± 1.1	0.2 ± 0.5
CAH	153.8 ± 67.8	112.9 ± 42.0	5.4 ± 1.4	1.8 ± 1.2
Cirrhosis	144.3 ± 49.2	142.0 ± 52.7	5.5 ± 1.7	4.0 ± 0.0

Values are presented as mean ± SD. Activity grade; 1-3 normal, 4-8 mild, 9-12 moderate, 12-18 severe. Fibrosis stage; 0 non, 1 mild, 2 moderate, 3 severe, and 4 cirrhosis.

Table 3 Histologic distribution of chronic HCV viral infection according to aminotransferases levels

	Normal AST n = 15	Abnormal AST n = 64
Old classification1
Normal	2	0
CPH	13	30
CAH	0	29
Cirrhosis	0	5
New classification
Overall activity	1.8 ± 0.8	3.7 ± 2.2
Fibrosis	0.06 ± 0.2	1.2 ± 1.4

¹Number of patients.