Molecular biology and the diagnosis and treatment of liver diseases

Table 1 Some inherited diseases that affect the liver and the genes that were indentified in the 1990s by molecular biological and genetic methods.

Disease	Gene
Wilson disease	Cu-transporting ATPase
Hereditary hemochromatosis	HFE
Crigler-Najjar syndrome	UDP-glucuronosyltransferase
Dubin-Johnson syndrome	cMOAT
Benign recurrent intrahepatic cholestasis	P-type ATPase
Progressive familial Intrahepatic Cholestasis Type 1	P-type ATPase

Table 2 HCV non-structural proteins with three-dimensional structures determined and published in the literature

Polypeptide	Function	Reference
NS3 protease domain	Protease that cleaves HCV polyprotein at several locations	75, 76
NS4A (complexed to NS3)	Cofactor for NS3 protease	76
NS3 RNA helicase domain	Unwinds viral RNA	77, 78