Expression of somatostatin mRNA in various differentiated types of gastric carcinoma

Table 1 In situ hybridization results in normal and various differentiated types of gastric carcinoma (^-x±s)

Histological types	Cases	Positive cases	Positive cells/mm-2
Normal gastric mucosa	15	13	7.3 ± 5.2b
Poorly differentiated carcinoma	9	9	201.3 ± 41.3d
Ring cell carcinoma	3	3	212.6 ± 58.3
Moderately differentiated carcinoma	9	7	40.0 ± 18.4f
Well-differentiated carcinoma	11	9	32.4 ± 15.4b

^bP < 0.01,

^dP < 0.01,

^fP < 0.01 vs carcinoma.

Table 2 Relationship between the in situ hybridization signals of somatostatin mRNA and clinical stages of gastric carcinoma

Clinical stage	Cases	Positive cases	Hybridization positive cells/mm2
I	5	2	39.2 ± 14.1
II	10	6	83.7 ± 36.2ab
III	14	11	130.5 ± 70.7
IV	3	1	133.5 ± 64.3d

^aP < 0.05 vs I,

^bP < 0.01 vs III;

^dP < 0.01 vs II.

Table 3 The correlation analysis of the expression between somatostatin mRNA and somatostatin immunoreactivity

Normal gastric mucosa		Gastric carcinoma
		Poorly differentiated	Moderately differentiated	Well differentiated
r	0.874	0.725	0.836	0.836
P	< 0.001	< 0.001	< 0.01	< 0.01