Integrating immune-inflammatory and nutritional indicators into machine learning-driven risk stratification for colorectal cancer

doi:10.3748/wjg.123195

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2027. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 123195
Published online Jan 14, 2027. doi: 10.3748/wjg.123195

Table 1 Baseline characteristics of the included colorectal cancer patients across four clinical centers, n (%)/median (Q1, Q3)

Characteristic	n = 10205
Sex
Male	5978 (58.6)
Female	4227 (41.4)
Age	65.00 (56.00, 72.00)
Smoking	3630 (35.6)
Drinking	3063 (30.0)
Hypertension	2751 (27.0)
T2DM	1305 (12.8)
CHD	566 (5.5)
NAT	665 (6.5)
Tumor location
Rectal	5273 (51.7)
Colon	4932 (48.3)
Tumor stage
I	2092 (20.5)
II	4089 (40.1)
III	3504 (34.3)
IV	520 (5.1)
Overall complications	2212 (21.7)
Major complications	179 (1.8)
Cardiovascular complications	179 (1.8)
Digestive complications	899 (8.8)
Respiratory complications	643 (6.3)
Nutritional and metabolic complications	571 (5.6)
Status	1850 (18.1)
Follow-up (month)	49.00 (28.00, 84.00)
CA19-9	11.39 (5.94, 22.60)
CEA	3.53 (2.01, 8.10)
NLR	2.61 (1.88, 3.79)
PLR	157.89 (117.35, 216.85)
LMR	3.48 (2.53, 4.71)
SII	568.70 (373.61, 931.67)
SIRI	1.03 (0.66, 1.69)
PIV	221.67 (129.44, 409.69)
PNI	47.35 (43.50, 51.00)
ALBI	-2.77 (-3.00, -2.50)
HALP	31.47 (19.57, 45.73)
FAR	0.09 (0.07, 0.10)
PAR	5.45 (4.30, 6.93)
NPR	0.02 (0.01, 0.02)
AGR	1.44 (1.27, 1.65)
AAPR	0.54 (0.45, 0.64)

AAPR: Albumin-to-alkaline phosphatase ratio; AGR: Albumin-to-globulin ratio; ALBI: Albumin-bilirubin index; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; CHD: Coronary heart disease; FAR: Fibrinogen-to-albumin ratio; HALP: Hemoglobin, albumin, lymphocyte, and platelet score; LMR: Lymphocyte-to-monocyte ratio NAT: Neoadjuvant therapy; NLR: Neutrophil-to-lymphocyte ratio; NPR: Neutrophil-to-platelet ratio; PAR: Platelet-to-albumin ratio; PIV: Pan-immune-inflammation value; PLR: Platelet-to-lymphocyte ratio; PNI: Prognostic nutritional index; SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; T2DM: Type 2 diabetes mellitus.

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Citation: Wang L, Liu C, Xie J, Liu JS, Zhou X, Liu F, Xiang CY, Zhao JN, Liu XR, Liu XY, Kang B, Cheng Y, Peng D. Integrating immune-inflammatory and nutritional indicators into machine learning-driven risk stratification for colorectal cancer. World J Gastroenterol 2027; 33(2): 123195
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/123195.htm
DOI: https://dx.doi.org/10.3748/wjg.123195

Wang L, Liu C, Xie J, Liu JS, Zhou X, Liu F, Xiang CY, Zhao JN, Liu XR, Liu XY, Kang B, Cheng Y, Peng D. Integrating immune-inflammatory and nutritional indicators into machine learning-driven risk stratification for colorectal cancer. World J Gastroenterol 2027; 33(2): 123195 [DOI: 10.3748/wjg.123195]

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