Cost-effectiveness of risk-stratified hepatocellular carcinoma screening using the age-male-albumin-bilirubin-platelets score-based stepwise enrichment approach in patients with cirrhosis

doi:10.3748/wjg.121840

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Dec 14, 2026; 32(46): 121840
Published online Dec 14, 2026. doi: 10.3748/wjg.121840

Table 1 Parameters for the stepwise enrichment approach of age-male-albumin-bilirubin-platelets scores used in the model[16]

Parameter	Base-case value	Uncertainty interval	Distribution
Proportion of individuals entering each stratification step
First: AMAP assessment	1
Second: AMAP-2 assessment	0.8953	0.7162-1	Triangular (0.7162, 0.8953, 1)
Third: AMAP-2 plus assessment	0.5094	0.4075-0.6113	Triangular (0.4075, 0.5093, 0.6113)
Identified as high-risk	0.2201	0.1761-0.2641	Triangular (0.1761, 0.2201, 0.2641)
Remainder as low-risk	0.7799	0.7359-0.8239	Triangular (0.7359, 0.7799, 0.8239)
Quarterly transition probability from cirrhosis to HCC
Low-risk	0.0020	0.0020-0.0024	Triangular (0.0020, 0.0020, 0.0024)
High-risk	0.0328	0.0263-0.0328	Triangular (0.0263, 0.0328, 0.0328)

aMAP: Age-male-albumin-bilirubin-platelets; HCC: Hepatocellular carcinoma.

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Citation: Zhang YB, Li YX, Zhang WD, Hou XB, Li R, Xia RY, Shen MW, Zou ZR, Zhuang GH. Cost-effectiveness of risk-stratified hepatocellular carcinoma screening using the age-male-albumin-bilirubin-platelets score-based stepwise enrichment approach in patients with cirrhosis. World J Gastroenterol 2026; 32(46): 121840
URL: https://www.wjgnet.com/1007-9327/full/v32/i46/121840.htm
DOI: https://dx.doi.org/10.3748/wjg.121840

Zhang YB, Li YX, Zhang WD, Hou XB, Li R, Xia RY, Shen MW, Zou ZR, Zhuang GH. Cost-effectiveness of risk-stratified hepatocellular carcinoma screening using the age-male-albumin-bilirubin-platelets score-based stepwise enrichment approach in patients with cirrhosis. World J Gastroenterol 2026; 32(46): 121840 [DOI: 10.3748/wjg.121840]

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