P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis

doi:10.3748/wjg.119965

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2026; 32(32): 119965
Published online Aug 28, 2026. doi: 10.3748/wjg.119965

Table 1 P-element-induced wimpy testis-interacting RNA as biomarker for gastric cancer diagnosis and prognosis

Biomarker	Biological process	Target area	Ref.
PiRNA-1245	Upregulated	Succus gastricus	[60]
FR290353	Upregulated	Gastric mucosa	[64]
FR064000	Upregulated	Gastric mucosa
FR387750	Upregulated	Gastric mucosa
piR-019308	Upregulated	Gastric mucosa	[61]
piR-004918	Upregulated	Gastric mucosa
piR-018569	Upregulated	Gastric mucosa
piR-651	Upregulated	Peripheral blood	[62]
piR-823	Upregulated	Peripheral blood	[62]
DQ570956	Downregulated	Gastric mucosa	[65]
DQ575659	Downregulated	Gastric mucosa
DQ597128	Downregulated	Gastric mucosa

PiRNA: P-element-induced wimpy testis-interacting RNA.

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Table 2 P-element-induced wimpy testis-interacting RNA and gastric cancer metastasis

PiRNA	Biological process	Target area	Function	Ref.
piR-823	Upregulated	Peripheral blood	Regulating PINK1/Parkin-mediated mitochondrial autophagy	[66-68]
piR-48966	Upregulated	Gastric mucosa	Regulating JNK and ERK signaling pathways to promote EMT transformation	[70]
piR-49145	Upregulated	Gastric mucosa
piR-31335	Upregulated	Gastric mucosa
piR-47851	Upregulated	Gastric mucosa	Regulating MAPK1 protein levels to inhibit gastric cancer cell proliferation	[72]

EMT: Epithelial–mesenchymal transition; ERK: Extracellular signal-regulated kinase; JNK: Janus kinase; MAPK1: Mitogen-activated protein kinase 1; PINK1: PTEN induced kinase 1; PiRNA: P-element-induced wimpy testis-interacting RNA; PIWI: P-element-induced wimpy testis.

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Table 3 P-element-induced wimpy testis-interacting RNA and development of gastric cancer

PiRNA	Biological process	Target area	Ref.
PIWIL1	Upregulated	Gastric mucosa	[74]
PIWIL2	Upregulated	Gastric mucosa	[74]
PIWIL1	Upregulated	Gastric mucosa	[75]
PIWIL3	Upregulated	Gastric mucosa	[76]

PiRNA: P-element-induced wimpy testis-interacting RNA; PIWIL: P-element-induced wimpy testis-like.

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Citation: Liu YW, Chen YK, Yan JY, Shen H, Mai FM, Kong ZH, Chen HL, Li LP, Liu WP, Gao Y, Zhang L. P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis. World J Gastroenterol 2026; 32(32): 119965
URL: https://www.wjgnet.com/1007-9327/full/v32/i32/119965.htm
DOI: https://dx.doi.org/10.3748/wjg.119965

Liu YW, Chen YK, Yan JY, Shen H, Mai FM, Kong ZH, Chen HL, Li LP, Liu WP, Gao Y, Zhang L. P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis. World J Gastroenterol 2026; 32(32): 119965 [DOI: 10.3748/wjg.119965]

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