Helicobacter pylori promotes gastric cancer progression by upregulating EPS8L3 to inhibit ferroptosis

Table 1 Correlation of epidermal growth factor receptor kinase substrate 8-like protein 3 expression with clinicopathologic parameters in gastric cancer patients

Variables	Cases	EPS8L3 expression		χ2	P value
		Low	High
Gender				2.51	0.113
Male	71	28	43
Female	36	20	16
Age (years)				0.12	0.732
< 61	56	26	30
≥ 61	51	22	29
Tumor location				0.78	0.377
Upper	36	14	22
Middle + lower	71	34	37
Tumor size (cm)				6.39	0.011a
< 6	48	28	20
> 6	59	20	39
Depth of invasion				6.86	0.009a
T1 + T2	29	19	10
T3 + T4	78	29	49
Differentiation				1.09	0.297
Well + moderate	41	21	20
Poor + undifferentiated	66	27	39
Lymph node metastasis				0.63	0.426
Absent	23	12	11
Present	84	36	48
TNM stage				0.10	0.755
I + II	34	16	18
III + IV	73	32	41

^aP < 0.05.

EPS8L3: Epidermal growth factor receptor kinase substrate 8-like protein 3; TNM: Tumor-node-metastasis.