Dysregulated signal transducer and activator of transcription 3 drives intestinal permeability and may contribute to acute-on-chronic liver failure

doi:10.3748/wjg.v32.i30.119465

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 14, 2026; 32(30): 119465
Published online Aug 14, 2026. doi: 10.3748/wjg.v32.i30.119465

Table 1 Primary antibodies, secondary antibodies, and target proteins

Primary antibody (clone)	Target (molecular weight)	Dilution	Supplier
Anti-claudin 1	CLDN1 (approximately 22 kDa)	1:200	Invitrogen
Anti-claudin 2	CLDN2 (approximately 22 kDa)	1:300	Invitrogen
Anti-claudin 3	CLDN3 (approximately 20 kDa)	1:1000	Invitrogen
Anti-β-actin (AC-15)	β-actin (42 kDa)	1:5000	Sigma-Aldrich
Anti-occludin	OCLN (65 kDa)	1:500	Invitrogen
Anti-phospho-STAT1 (Tyr701) (58D6)	pSTAT1 (approximately 85 kDa)	1:500	Cell Signaling Technology
Anti-phospho-STAT3 (Tyr705) (D3A7)	pSTAT3 (approximately 80 kDa)	1:250	Cell Signaling Technology
Anti-STAT1 (42H3)	STAT1 (approximately 91 kDa)	1:1000	Cell Signaling Technology
Anti-STAT3 (124H6)	STAT3 (79-86 kDa)	1:1000	Cell Signaling Technology
Anti-ZO-1 monoclonal antibody (ZO1-1A12)	ZO-1 (225 kDa)	1:250	Invitrogen
Anti-ZO-1 monoclonal antibody (ZO-1A12, FITC)	ZO-1 (225 kDa)	1:500	Invitrogen
HRP-linked anti-mouse IgG	HRP-linked anti-mouse IgG	1:5000	Cell Signaling Technology
HRP-linked anti-rabbit IgG	HRP-linked anti-rabbit IgG	1:5000	Cell Signaling Technology

CLDN: Claudin; OCLN: Occludin; STAT: Signal transducer and activator of transcription; ZO-1: Zonula occludens-1; FITC: Fluorescein isothiocyanate; HRP: Horseradish peroxidase; IgG: Immunoglobulin G.

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Citation: Leinz N, Beyer S, Yoganathan-Kugarajan B, Kraus N, Ortiz C, Hahnefeld L, Gurke R, Başoğlu M, Plotz G, Eimer S, Zeuzem S, Trebicka J, Welsch C, Brieger A. Dysregulated signal transducer and activator of transcription 3 drives intestinal permeability and may contribute to acute-on-chronic liver failure. World J Gastroenterol 2026; 32(30): 119465
URL: https://www.wjgnet.com/1007-9327/full/v32/i30/119465.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i30.119465

Leinz N, Beyer S, Yoganathan-Kugarajan B, Kraus N, Ortiz C, Hahnefeld L, Gurke R, Başoğlu M, Plotz G, Eimer S, Zeuzem S, Trebicka J, Welsch C, Brieger A. Dysregulated signal transducer and activator of transcription 3 drives intestinal permeability and may contribute to acute-on-chronic liver failure. World J Gastroenterol 2026; 32(30): 119465 [DOI: 10.3748/wjg.v32.i30.119465]

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