Endoscopic diagnosis of non-erosive reflux disease

Table 1 The detailed characteristics of minimal change lesions in non-erosive reflux disease

Endoscopic change type	Category	Endoscopic feature	Detailed characteristics
Microvascular alteration	Core feature	IPCL abnormalities	Increased number, dilation, and tortuosity of IPCLs
	Supportive feature	Increased vascularity at the SCJ	Dilated, dark-brown capillaries immediately below the SCJ
Mucosal alteration	Core feature	Ridge/villous pattern	Uniform, longitudinally aligned ridges alternating with a villiform pattern
		Microerosions	Mucosal breaks visible only with image-enhanced endoscopy
	Supportive feature	Islands of columnar epithelium	Dark-brown columnar islands surrounded by white squamous mucosa
		Reduced vascularity	Heterogeneous vascular pattern with areas of decreased vascularity
		Blurred Z-line	Indefinite Z-line border
		Accentuated edema or mucosal folds	Prominent gastric-type folds at the SCJ

IPCL: Intrapapillary capillary loop; SCJ: Squamocolumar junction.