Enhancing delivery of doxorubicin using triolein emulsion in rabbit VX2 liver tumor model

doi:10.3748/wjg.119374

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 7, 2026; 32(29): 119374
Published online Aug 7, 2026. doi: 10.3748/wjg.119374

Table 1 VX2 tumor volume of pre-transcatheter arterial chemoembolization computed tomography and post-transcatheter arterial chemoembolization computed tomography after doxorubicin transcatheter arterial chemoembolization with and without triolein emulsion in a rabbit liver, mean ± SD

	Tumor volume; (V9/Vb - 1) × 100
	Pre-TACE CT (Vb)	Post-TACE CT (V9)
TE-Doxo (n = 8)	1913.09 ± 489.58	1229.75 ± 395.61
NS-Doxo (n = 6)	874.36 ± 361.65	1574.17 ± 890.12

TE-Doxo: Triolein emulsion with doxorubicin group; NS-Doxo: Normal saline with doxorubicin group; TACE: Transcatheter arterial chemoembolization; CT: Computed tomography.

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Table 2 Longitudinal changes in the growth ratio of VX2 tumor volume measured by computed tomography before and 9 days after doxorubicin-based transcatheter arterial chemoembolization in rabbit liver tumors treated with triolein emulsion and normal saline, mean ± SD

	Growth ratio
TE-Doxo (n = 8)	-41.68 ± 7.32
NS-Doxo (n = 6)	76.59 ± 77.51

Negative values indicate tumor volume reduction, whereas positive values indicate tumor volume increase. TE-Doxo: Triolein emulsion with doxorubicin group; NS-Doxo: Normal saline with doxorubicin group.

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Citation: Kim YW, Kim HJ, Choi SH, Yun MS. Enhancing delivery of doxorubicin using triolein emulsion in rabbit VX2 liver tumor model. World J Gastroenterol 2026; 32(29): 119374
URL: https://www.wjgnet.com/1007-9327/full/v32/i29/119374.htm
DOI: https://dx.doi.org/10.3748/wjg.119374

Kim YW, Kim HJ, Choi SH, Yun MS. Enhancing delivery of doxorubicin using triolein emulsion in rabbit VX2 liver tumor model. World J Gastroenterol 2026; 32(29): 119374 [DOI: 10.3748/wjg.119374]

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