Impairment of the intestinal epithelium barrier through alteration of proliferation and differentiation balance in alcohol use disorder

doi:10.3748/wjg.118458

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 28, 2026; 32(28): 118458
Published online Jul 28, 2026. doi: 10.3748/wjg.118458

Table 1 Clinical parameters healthy and alcohol use disorder patients, mean ± SD

	Healthy	Alcohol use disorder
Demographics	n = 14	n = 46
Age (years)	48.4 ± 15.2	48.7 ± 12
Gender (female/male)	6/8	18/28
Body mass index	24.7 ± 2.5	24.8 ± 4.2
Alcohol (g/day)		182.7 ± 85.6
Biochemistry
AST (U/L)	ND	86 ± 106
ALT (U/L)	ND	63 ± 65
GGT (U/L)	ND	204 ± 318
ALP (U/L)	ND	90 ± 36
Bilirubin (mg/dL)	ND	0.6 ± 0.4
Albumin (g/L)	ND	47 ± 3
INR	ND	0.99 ± 0.09
Creatinine (mg/dL)	ND	0.77 ± 0.14
Fibroscan^®
Liver stiffness (kPa)	ND	8.1 ± 6.5
Controlled attenuation parameter (dB/m), grading/staging	ND	276 ± 53
Steatosis (S0/S1/S2/S3)	ND	8/7/16/15
Fibrosis (F0-1/F2/F3/F4)	ND	31/8/4/3

ND: Not done; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; INR: International ratio.

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Citation: Toulehohoun AG, Ambroise J, Illiyas B, Maccioni L, Lupianez J, Manco R, Clerbaux LA, Bouzin C, Schnabl B, Stärkel P. Impairment of the intestinal epithelium barrier through alteration of proliferation and differentiation balance in alcohol use disorder. World J Gastroenterol 2026; 32(28): 118458
URL: https://www.wjgnet.com/1007-9327/full/v32/i28/118458.htm
DOI: https://dx.doi.org/10.3748/wjg.118458

Toulehohoun AG, Ambroise J, Illiyas B, Maccioni L, Lupianez J, Manco R, Clerbaux LA, Bouzin C, Schnabl B, Stärkel P. Impairment of the intestinal epithelium barrier through alteration of proliferation and differentiation balance in alcohol use disorder. World J Gastroenterol 2026; 32(28): 118458 [DOI: 10.3748/wjg.118458]

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